node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTG1 | ALB | ENSOARP00000019868 | ENSOARP00000014782 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.848 |
ACTG1 | CTSB | ENSOARP00000019868 | ENSOARP00000016378 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.413 |
ACTG1 | EEA1 | ENSOARP00000019868 | ENSOARP00000016984 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Early endosome antigen 1. | 0.622 |
ACTG1 | LAMP1 | ENSOARP00000019868 | ENSOARP00000008813 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Lysosomal associated membrane protein 1. | 0.648 |
ACTG1 | LAMP2 | ENSOARP00000019868 | ENSOARP00000014124 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Lysosomal associated membrane protein 2. | 0.400 |
ALB | ACTG1 | ENSOARP00000014782 | ENSOARP00000019868 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.848 |
ALB | CTSB | ENSOARP00000014782 | ENSOARP00000016378 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.598 |
ALB | EEA1 | ENSOARP00000014782 | ENSOARP00000016984 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Early endosome antigen 1. | 0.831 |
ALB | LAMP1 | ENSOARP00000014782 | ENSOARP00000008813 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Lysosomal associated membrane protein 1. | 0.709 |
ALB | LAMP2 | ENSOARP00000014782 | ENSOARP00000014124 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Lysosomal associated membrane protein 2. | 0.585 |
APPL1 | EEA1 | ENSOARP00000015590 | ENSOARP00000016984 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Early endosome antigen 1. | 0.860 |
APPL1 | RAB22A | ENSOARP00000015590 | ENSOARP00000018449 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | RAB22A, member RAS oncogene family. | 0.809 |
APPL1 | RAB5B | ENSOARP00000015590 | ENSOARP00000011427 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | RAB5B, member RAS oncogene family. | 0.810 |
APPL1 | RAB5C | ENSOARP00000015590 | ENSOARP00000020155 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Uncharacterized protein. | 0.868 |
CCZ1 | EEA1 | ENSOARP00000001111 | ENSOARP00000016984 | Uncharacterized protein. | Early endosome antigen 1. | 0.595 |
CCZ1 | LAMP1 | ENSOARP00000001111 | ENSOARP00000008813 | Uncharacterized protein. | Lysosomal associated membrane protein 1. | 0.401 |
CCZ1 | MON1A | ENSOARP00000001111 | ENSOARP00000012087 | Uncharacterized protein. | MON1 homolog A, secretory trafficking associated. | 0.986 |
CCZ1 | RAB5C | ENSOARP00000001111 | ENSOARP00000020155 | Uncharacterized protein. | Uncharacterized protein. | 0.586 |
CCZ1 | TBC1D15 | ENSOARP00000001111 | ENSOARP00000015735 | Uncharacterized protein. | TBC1 domain family member 15. | 0.439 |
CCZ1 | VPS33A | ENSOARP00000001111 | ENSOARP00000012369 | Uncharacterized protein. | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. | 0.883 |