STRINGSTRING
ABCA12 ABCA12 ATP8 ATP8 HYI HYI RIOX1 RIOX1 GCNT3 GCNT3 CARS-2 CARS-2 STAT3 STAT3 CARS CARS PNPT1 PNPT1 MYOF MYOF RETN RETN SLC14A1 SLC14A1 SLC22A18 SLC22A18 IGHM IGHM LRRC8E LRRC8E LOC101119944 LOC101119944 LEMD3 LEMD3 LGALS3BP LGALS3BP HK3 HK3 SLC12A4 SLC12A4 NCOA2 NCOA2 SEC23IP SEC23IP AP1B1 AP1B1 ALDOA ALDOA PKLR PKLR GPI GPI HSD17B11 HSD17B11 PEX14 PEX14 DNASE1L1 DNASE1L1 MSN MSN HKDC1 HKDC1 CLIC1 CLIC1 HK1 HK1 SLC26A2 SLC26A2 EEF1A1 EEF1A1 AP2B1 AP2B1 LDHD LDHD CLIC4 CLIC4 SERPINB12 SERPINB12 CARKD CARKD SLC26A3 SLC26A3 TAF4B TAF4B DLD DLD SLC44A1 SLC44A1 ME1 ME1 STAT6 STAT6 BPGM BPGM RPL34 RPL34 GAPDH GAPDH MRPL48 MRPL48 PRPF40A PRPF40A SLCO2A1 SLCO2A1 W5PFN6_SHEEP W5PFN6_SHEEP FH FH STAT2 STAT2 CS CS ENO1 ENO1 LDHA LDHA AZU1 AZU1 NCOA3 NCOA3 W5PK04_SHEEP W5PK04_SHEEP PARK7 PARK7 DEK DEK SLC18A1 SLC18A1 SLC1A5 SLC1A5 GOSR1 GOSR1 EEF1A2 EEF1A2 CBS CBS SLC30A1 SLC30A1 SLC5A1 SLC5A1 IDH2 IDH2 DCTN1 DCTN1 TRPM4 TRPM4 HK2 HK2 LSS LSS PITRM1 PITRM1 IL1R2 IL1R2 PGAM2 PGAM2 RHOA RHOA STAT1 STAT1 PCBD2 PCBD2 CLCA2 CLCA2 OGDH OGDH GLO1 GLO1 ABCA13 ABCA13 DLAT DLAT SLC9A3 SLC9A3 W5Q3R0_SHEEP W5Q3R0_SHEEP SLC40A1 SLC40A1 SLC27A1 SLC27A1 HAGH HAGH FGG FGG NOS2 NOS2 SLC44A2 SLC44A2 TRPV3 TRPV3 LOC101103784 LOC101103784 SLC44A3 SLC44A3 SLC3A2 SLC3A2 CLCN1 CLCN1 NCOA1 NCOA1 ACO2 ACO2 SLC30A7 SLC30A7 PDHX PDHX FASTKD2 FASTKD2 PGK1 PGK1 PDIA4 PDIA4 PKM PKM STAT5B STAT5B ADPGK ADPGK IDH1 IDH1 PCK2 PCK2 GSTM3 GSTM3 PSMB5 PSMB5 ANO6 ANO6 SLC16A1 SLC16A1 SLC12A6 SLC12A6 AP4B1 AP4B1 SLC1A4 SLC1A4 SLC27A2 SLC27A2 SYNE2 SYNE2 LOC101107359 LOC101107359
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (66 aa)
HYIHydroxypyruvate isomerase (putative). (227 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (575 aa)
GCNT3Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I- branching enzyme activity by converting linear into branched poly-N- acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. (440 aa)
CARS-2tRNA-synt_1e domain-containing protein. (207 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
CARSCysteinyl-tRNA synthetase. (581 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (785 aa)
MYOFMyoferlin. (2049 aa)
RETNUncharacterized protein. (109 aa)
SLC14A1Urea transporter 1; Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across [...] (439 aa)
SLC22A18Solute carrier family 22 member 18. (549 aa)
IGHMImmunoglobulin heavy constant mu. (456 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (578 aa)
LOC101119944Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (459 aa)
LEMD3LEM domain containing 3. (856 aa)
LGALS3BPGalectin 3 binding protein. (536 aa)
HK3Hexokinase 3. (951 aa)
SLC12A4Uncharacterized protein. (1050 aa)
NCOA2Nuclear receptor coactivator. (1465 aa)
SEC23IPSEC23 interacting protein. (1026 aa)
AP1B1AP complex subunit beta. (940 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
HSD17B11Hydroxysteroid 17-beta dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
PEX14Peroxisomal biogenesis factor 14. (374 aa)
DNASE1L1Deoxyribonuclease 1 like 1. (325 aa)
MSNMoesin. (665 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (251 aa)
HK1Hexokinase 1. (921 aa)
SLC26A2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (734 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
AP2B1AP complex subunit beta. (951 aa)
LDHDLactate dehydrogenase D. (498 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
SERPINB12Serpin family B member 12; Belongs to the serpin family. (425 aa)
CARKDATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (316 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (760 aa)
TAF4BTATA-box binding protein associated factor 4b. (871 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (659 aa)
ME1Malic enzyme. (545 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
BPGMPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
RPL34Uncharacterized protein. (128 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
MRPL48Mitochondrial ribosomal protein L48. (212 aa)
PRPF40APre-mRNA processing factor 40 homolog A. (879 aa)
SLCO2A1Solute carrier organic anion transporter family member. (655 aa)
W5PFN6_SHEEPElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (385 aa)
FHFumarate hydratase. (510 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
ENO1Enolase 1. (452 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
AZU1Azurocidin 1. (247 aa)
NCOA3Nuclear receptor coactivator. (1413 aa)
W5PK04_SHEEPPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (200 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
DEKDEK proto-oncogene. (367 aa)
SLC18A1Solute carrier family 18 member A1. (524 aa)
SLC1A5Amino acid transporter. (546 aa)
GOSR1Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. (250 aa)
EEF1A2Eukaryotic translation elongation factor 1 alpha 2. (512 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
SLC30A1Solute carrier family 30 member 1. (484 aa)
SLC5A1Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (664 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
DCTN1CAP-Gly domain-containing protein. (1297 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1202 aa)
HK2Hexokinase 2. (922 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (733 aa)
PITRM1Pitrilysin metallopeptidase 1. (1030 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
RHOARHOA. (193 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
PCBD2Pterin-4 alpha-carbinolamine dehydratase 2. (102 aa)
CLCA2Chloride channel accessory 2. (1022 aa)
OGDHOxoglutarate dehydrogenase. (1023 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (188 aa)
ABCA13ATP binding cassette subfamily A member 13. (4975 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (755 aa)
W5Q3R0_SHEEPElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (422 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (574 aa)
SLC27A1Solute carrier family 27 member 1. (524 aa)
HAGHHydroxyacylglutathione hydrolase. (308 aa)
FGGFibrinogen gamma chain. (434 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (705 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
LOC101103784Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (649 aa)
SLC3A2Solute carrier family 3 member 2. (577 aa)
CLCN1Chloride channel protein. (1063 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
SLC30A7Uncharacterized protein. (376 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
FASTKD2FAST kinase domains 2. (688 aa)
PGK1Phosphoglycerate kinase. (420 aa)
PDIA4Protein disulfide-isomerase. (647 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (567 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
ADPGKADP dependent glucokinase. (435 aa)
IDH1Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (724 aa)
GSTM3Glutathione S-transferase. (230 aa)
PSMB5Proteasome subunit beta. (263 aa)
ANO6Anoctamin. (964 aa)
SLC16A1MFS domain-containing protein. (501 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (741 aa)
SLC1A4Solute carrier family 1 member 4. (497 aa)
SLC27A2Solute carrier family 27 member 2. (618 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6879 aa)
LOC101107359Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.