STRINGSTRING
IL1A IL1A KIT KIT CLDN11 CLDN11 HMGB4 HMGB4 HERC5 HERC5 ESX1 ESX1 DEFB123 DEFB123 MLLT10 MLLT10 CALCR CALCR FBXO39 FBXO39 NDUFV2 NDUFV2 ITGA6 ITGA6 PSMG4 PSMG4 TMEM190 TMEM190 BMI1 BMI1 NASP NASP FGF1 FGF1 ADAM2 ADAM2 CYP17A1 CYP17A1 SLC2A3 SLC2A3 RETN RETN S100A13 S100A13 CCDC117 CCDC117 GTF2A1 GTF2A1 PEBP1 PEBP1 CXCL12 CXCL12 SGF29 SGF29 TIMP2 TIMP2 MDK MDK CYP11A1 CYP11A1 RET RET STRA6 STRA6 TSPAN33 TSPAN33 TOP2B TOP2B FSHR FSHR TULP4 TULP4 RARB RARB YWHAB YWHAB HELLS HELLS TMEM147 TMEM147 SLPI SLPI ST3GAL2 ST3GAL2 SUN5 SUN5 CARHSP1 CARHSP1 TKTL1 TKTL1 ETV4 ETV4 WDR82 WDR82 SPACA9 SPACA9 FOXO1 FOXO1 GPATCH4 GPATCH4 PDGFA PDGFA HORMAD2 HORMAD2 SETX SETX DMRTB1 DMRTB1 NDUFA4 NDUFA4 CSF1R CSF1R SSR4 SSR4 PDGFRB PDGFRB TNP2 TNP2 PRM3 PRM3 STPG1 STPG1 TRMT112 TRMT112 HMGN3 HMGN3 PSMA8 PSMA8 KLF4 KLF4 TEX29 TEX29 CD74 CD74 W5PBV5_SHEEP W5PBV5_SHEEP CHD4 CHD4 DDX4 DDX4 LYAR LYAR SIVA1 SIVA1 HUWE1 HUWE1 RBBP8 RBBP8 NME8 NME8 STRA8 STRA8 TEX101 TEX101 PTCH1 PTCH1 SMC1A SMC1A GAS6 GAS6 FATE1 FATE1 NKAPL NKAPL KNTC1 KNTC1 W5PIE5_SHEEP W5PIE5_SHEEP ENO1 ENO1 PLPPR3 PLPPR3 ALDH1A3 ALDH1A3 BCL6B BCL6B PIWIL4 PIWIL4 FMR1 FMR1 PTN PTN SMC3 SMC3 KLC3 KLC3 SMCHD1 SMCHD1 ACVR2A ACVR2A SPACA3 SPACA3 JUN JUN IGF1R IGF1R AKAP4 AKAP4 LPIN2 LPIN2 SYCE2 SYCE2 RAD21 RAD21 CCNA1 CCNA1 CXCR4 CXCR4 KDM1B KDM1B PAX7 PAX7 FOXO3 FOXO3 CLEC3B CLEC3B VIM VIM NANOS2 NANOS2 WASHC1 WASHC1 CYP26B1 CYP26B1 CCDC38 CCDC38 W5PQU9_SHEEP W5PQU9_SHEEP ZPBP2 ZPBP2 FZR1 FZR1 ANXA1 ANXA1 ALDH1A1 ALDH1A1 RBM47 RBM47 ASB17 ASB17 SPACA1 SPACA1 UCHL1 UCHL1 DMRT1 DMRT1 SPEM1 SPEM1 NR6A1 NR6A1 NR5A1 NR5A1 SOX9 SOX9 ALB ALB RHOA RHOA STRBP STRBP LGALS1 LGALS1 RARA RARA CCDC124 CCDC124 TDRD1 TDRD1 FTH1 FTH1 AMH AMH ELAVL2 ELAVL2 AR AR IZUMO4 IZUMO4 INCENP INCENP NKG7 NKG7 LOC101113728 LOC101113728 ZNF518A ZNF518A UTF1 UTF1 INSL3 INSL3 IRF1 IRF1 SHBG SHBG GATA4 GATA4 SYCP3 SYCP3 EIF1AX EIF1AX DAZL DAZL DMC1 DMC1 KITLG KITLG PTPRC PTPRC BTG3 BTG3 NME5 NME5 CXADR CXADR FGFR3 FGFR3 TSPAN5 TSPAN5 ATP5F1E ATP5F1E GFRA1 GFRA1 SUN3 SUN3 PIWIL1 PIWIL1 WT1 WT1 CCDC112 CCDC112 EGR1 EGR1 MLH1 MLH1 TMEM89 TMEM89 MEIOB MEIOB W5Q5L3_SHEEP W5Q5L3_SHEEP SPATA22 SPATA22 VPS29 VPS29 F2R F2R ODF1 ODF1 PARD3 PARD3 ACVR1B ACVR1B ECSCR ECSCR PROS1 PROS1 PLK1 PLK1 ITGB1 ITGB1 FTH1-2 FTH1-2 CHD1 CHD1 POMC POMC AURKA AURKA DNAJB8 DNAJB8 RAD21L1 RAD21L1 CD44 CD44 AURKB AURKB PDGFRA PDGFRA KLF2 KLF2 DPPA4 DPPA4 REC8 REC8 CSF1 CSF1 TPPP2 TPPP2 NGF NGF ITGB5 ITGB5 INHA INHA TYRO3 TYRO3 HSD3B1 HSD3B1 MPL MPL ETV5 ETV5 SPATA3 SPATA3 SPATA16 SPATA16 IL1B IL1B CLEC12B CLEC12B OAZ3 OAZ3 KLRF1 KLRF1 TNFRSF1A TNFRSF1A
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (309 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
HMGB4High mobility group box 4. (194 aa)
HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1039 aa)
ESX1Homeobox domain-containing protein. (284 aa)
DEFB123Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
MLLT10MLLT10 histone lysine methyltransferase DOT1L cofactor. (954 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (508 aa)
FBXO39F-box protein 39. (443 aa)
NDUFV2Uncharacterized protein. (246 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1069 aa)
PSMG4Proteasome assembly chaperone 4. (102 aa)
TMEM190Transmembrane protein 190. (180 aa)
BMI1RING-type domain-containing protein. (326 aa)
NASPUncharacterized protein. (778 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa)
ADAM2ADAM metallopeptidase domain 2. (741 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa)
SLC2A3Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. (494 aa)
RETNUncharacterized protein. (109 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
CCDC117Coiled-coil domain containing 117. (278 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
PEBP1Uncharacterized protein. (187 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (147 aa)
SGF29SAGA complex associated factor 29. (293 aa)
TIMP2NTR domain-containing protein. (217 aa)
MDKMidkine. (143 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (By similarity). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into [...] (520 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1123 aa)
STRA6Stimulated by retinoic acid 6. (744 aa)
TSPAN33Tetraspanin. (267 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1613 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity). (656 aa)
TULP4TUB like protein 4. (1160 aa)
RARBRetinoic acid receptor beta. (448 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (282 aa)
HELLSHelicase, lymphoid specific. (837 aa)
TMEM147Transmembrane protein 147. (247 aa)
SLPIAntileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance t [...] (140 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (370 aa)
SUN5Sad1 and UNC84 domain containing 5. (380 aa)
CARHSP1Calcium regulated heat stable protein 1. (159 aa)
TKTL1Transketolase like 1. (622 aa)
ETV4ETS variant 4. (486 aa)
WDR82WD repeat domain 82. (313 aa)
SPACA9Sperm acrosome associated 9. (223 aa)
FOXO1Fork-head domain-containing protein. (445 aa)
GPATCH4G-patch domain containing 4. (406 aa)
PDGFAPlatelet derived growth factor subunit A. (187 aa)
HORMAD2HORMA domain containing 2. (308 aa)
SETXSenataxin. (2662 aa)
DMRTB1DMRT like family B with proline rich C-terminal 1. (368 aa)
NDUFA4Uncharacterized protein. (82 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
SSR4Signal sequence receptor subunit 4. (173 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
TNP2Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (136 aa)
PRM3Protamine 3. (93 aa)
STPG1Sperm tail PG-rich repeat containing 1. (335 aa)
TRMT112tRNA methyltransferase subunit 11-2. (125 aa)
HMGN3High mobility group nucleosomal binding domain 3. (95 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
KLF4Uncharacterized protein. (340 aa)
TEX29Testis expressed 29. (162 aa)
CD74CD74 molecule. (294 aa)
W5PBV5_SHEEPPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (380 aa)
CHD4Uncharacterized protein. (1881 aa)
DDX4DEAD-box helicase 4; Belongs to the DEAD box helicase family. (732 aa)
LYARLy1 antibody reactive. (382 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (176 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4418 aa)
RBBP8Uncharacterized protein. (887 aa)
NME8NME/NM23 family member 8. (588 aa)
STRA8Stimulated by retinoic acid 8. (366 aa)
TEX101UPAR/Ly6 domain-containing protein. (253 aa)
PTCH1Patched 1. (1450 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
GAS6Growth arrest specific 6. (594 aa)
FATE1Miff domain-containing protein. (180 aa)
NKAPLNFKB activating protein like. (399 aa)
KNTC1Kinetochore associated 1. (2242 aa)
W5PIE5_SHEEPHMG box domain-containing protein. (237 aa)
ENO1Enolase 1. (452 aa)
PLPPR3Phospholipid phosphatase related 3. (716 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (493 aa)
BCL6BBCL6B transcription repressor. (473 aa)
PIWIL4Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. (854 aa)
FMR1Fragile X mental retardation 1. (632 aa)
PTNPleiotrophin. (168 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
KLC3Kinesin light chain 3. (495 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1872 aa)
ACVR2AActivin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
SPACA3Sperm acrosome associated 3; Belongs to the glycosyl hydrolase 22 family. (163 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (312 aa)
IGF1RTyrosine-protein kinase receptor. (1122 aa)
AKAP4A-kinase anchoring protein 4. (860 aa)
LPIN2Lipin 2. (889 aa)
SYCE2Synaptonemal complex central element protein 2. (184 aa)
RAD21RAD21 cohesin complex component. (630 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (454 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
KDM1BLysine demethylase 1B. (821 aa)
PAX7Paired box 7. (501 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
CLEC3BC-type lectin domain family 3 member B. (205 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (467 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
WASHC1WH2 domain-containing protein. (269 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CCDC38Coiled-coil domain containing 38. (564 aa)
W5PQU9_SHEEPUncharacterized protein. (170 aa)
ZPBP2Zona pellucida binding protein 2. (326 aa)
FZR1WD_REPEATS_REGION domain-containing protein. (493 aa)
ANXA1Annexin. (346 aa)
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo. (501 aa)
RBM47RNA binding motif protein 47. (548 aa)
ASB17Ankyrin repeat and SOCS box containing 17. (295 aa)
SPACA1Sperm acrosome associated 1. (292 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (252 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (332 aa)
SPEM1Spermatid maturation 1. (313 aa)
NR6A1Nuclear receptor subfamily 6 group A member 1. (434 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (439 aa)
SOX9SRY-box transcription factor 9. (383 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
RHOARHOA. (193 aa)
STRBPUncharacterized protein. (676 aa)
LGALS1Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase (By similarity). Strong inducer of T-cell apoptosis. (108 aa)
RARARetinoic acid receptor alpha. (453 aa)
CCDC124Uncharacterized protein. (149 aa)
TDRD1Uncharacterized protein. (1197 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (154 aa)
AMHAMH_N domain-containing protein. (213 aa)
ELAVL2ELAV-like protein; Belongs to the RRM elav family. (388 aa)
ARAndrogen receptor. (881 aa)
IZUMO4IZUMO family member 4. (201 aa)
INCENPInner centromere protein. (866 aa)
NKG7Natural killer cell granule protein 7. (157 aa)
LOC101113728Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (446 aa)
ZNF518AZinc finger protein 518A. (1480 aa)
UTF1Uncharacterized protein. (108 aa)
INSL3Insulin-like protein 3. (131 aa)
IRF1Interferon regulatory factor. (322 aa)
SHBGSex hormone binding globulin. (425 aa)
GATA4GATA binding protein 4. (346 aa)
SYCP3Synaptonemal complex protein 3. (225 aa)
EIF1AXX-linked eukaryotic translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (144 aa)
DAZLDeleted in azoospermia like. (258 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
KITLGSoluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (274 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1235 aa)
BTG3B cell translocation protein 3. (252 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (209 aa)
CXADRUncharacterized protein. (365 aa)
FGFR3Fibroblast growth factor receptor 3. (664 aa)
TSPAN5Tetraspanin. (226 aa)
ATP5F1EATP synthase F1 subunit epsilon. (51 aa)
GFRA1GDNF family receptor alpha 1. (335 aa)
SUN3Sad1 and UNC84 domain containing 3. (359 aa)
PIWIL1Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (935 aa)
WT1WT1 transcription factor. (450 aa)
CCDC112Coiled-coil domain containing 112. (512 aa)
EGR1DUF3446 domain-containing protein. (298 aa)
MLH1MutL homolog 1. (758 aa)
TMEM89Transmembrane protein 89. (159 aa)
MEIOBUncharacterized protein. (202 aa)
W5Q5L3_SHEEPUncharacterized protein. (4513 aa)
SPATA22Spermatogenesis associated 22. (326 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (186 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
ODF1Outer dense fiber of sperm tails 1. (259 aa)
PARD3Par-3 family cell polarity regulator. (1328 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (468 aa)
ECSCRUncharacterized protein. (245 aa)
PROS1Protein S. (675 aa)
PLK1Serine/threonine-protein kinase PLK. (605 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
FTH1-2Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). (233 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1716 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. (254 aa)
AURKAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
DNAJB8Uncharacterized protein. (96 aa)
RAD21L1RAD21 cohesin complex component like 1. (554 aa)
CD44CD44 molecule (Indian blood group). (705 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (406 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
KLF2Uncharacterized protein. (112 aa)
DPPA4DCR domain-containing protein. (309 aa)
REC8REC8 meiotic recombination protein. (592 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
TPPP2Tubulin polymerization promoting protein family member 2. (171 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (388 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa)
TYRO3TYRO3 protein tyrosine kinase. (817 aa)
HSD3B13Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (375 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (633 aa)
ETV5ETS variant 5. (551 aa)
SPATA3Uncharacterized protein. (229 aa)
SPATA16Spermatogenesis associated 16. (562 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CLEC12BC-type lectin domain family 12 member B. (274 aa)
OAZ3Ornithine decarboxylase antizyme 3. (234 aa)
KLRF1Killer cell lectin like receptor F1. (235 aa)
TNFRSF1AUncharacterized protein. (277 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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