STRINGSTRING
LOC114110327 LOC114110327 ND4 ND4 ND5 ND5 ASL ASL KDR KDR BTG2 BTG2 RPS3A-2 RPS3A-2 FOS FOS CCDC40 CCDC40 ACTA1 ACTA1 ESR1 ESR1 ACTN2 ACTN2 RPS5 RPS5 LOC100037668 LOC100037668 RPS3A RPS3A GMNN GMNN RPS3A-3 RPS3A-3 ITGB6 ITGB6 GAS2 GAS2 ASS1 ASS1 C1QA C1QA PRIM1 PRIM1 TYMS TYMS PTPN11 PTPN11 GNRH1 GNRH1 PROM1 PROM1 MX2 MX2 RPS15A RPS15A MCM6 MCM6 RPL21 RPL21 RPL8 RPL8 JAK2 JAK2 DNAH5 DNAH5 CDKN1A CDKN1A ARG1 ARG1 RPS20 RPS20 FEN1 FEN1 PTPRC PTPRC DSCC1 DSCC1 RPS3A-4 RPS3A-4 MCMDC2 MCMDC2 CDK6 CDK6 CD44 CD44 RPS3A-5 RPS3A-5 RPS3A-6 RPS3A-6 RPS3A-7 RPS3A-7 CCDC39 CCDC39 ARG2 ARG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC114110327Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family. (191 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (606 aa)
ASLUncharacterized protein. (468 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
BTG2Uncharacterized protein. (162 aa)
RPS3A-240S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (242 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (377 aa)
CCDC40Coiled-coil domain containing 40. (1141 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
ACTN2Actinin alpha 2. (896 aa)
RPS5Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
LOC100037668Uncharacterized protein; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
GMNNGeminin DNA replication inhibitor. (187 aa)
RPS3A-340S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
GAS2Growth arrest specific 2. (314 aa)
ASS1Argininosuccinate synthase 1. (410 aa)
C1QAComplement C1q A chain. (244 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
TYMSThymidylate synthetase. (352 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. (96 aa)
PROM1Prominin 1. (879 aa)
MX2Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity. (713 aa)
RPS15ARibosomal protein S15a. (130 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
RPL21Uncharacterized protein. (161 aa)
RPL8Ribosomal protein L8. (257 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
DNAH5Dynein axonemal heavy chain 5. (4630 aa)
CDKN1AUncharacterized protein. (163 aa)
ARG1Arginase. (352 aa)
RPS20Ribosomal_S10 domain-containing protein. (119 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1235 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (324 aa)
RPS3A-440S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
CDK6Cyclin dependent kinase 6. (273 aa)
CD44CD44 molecule (Indian blood group). (705 aa)
RPS3A-540S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPS3A-640S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPS3A-740S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
ARG2Arginase. (354 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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