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GPX7 GPX7 IL10 IL10 GAS2 GAS2 GPX3 GPX3 GPX8 GPX8 IL6 IL6 ALB ALB ARG1 ARG1 KEAP1 KEAP1 TLR6 TLR6 TLR1 TLR1 GPX5 GPX5 GOT1 GOT1 GPX6 GPX6 GPX2 GPX2 ARG2 ARG2 GOT2 GOT2 SOD2 SOD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (165 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
GAS2Growth arrest specific 2. (314 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (151 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
ARG1Arginase. (352 aa)
KEAP1Kelch like ECH associated protein 1. (615 aa)
TLR6Toll-like receptor. (797 aa)
TLR1Toll-like receptor. (796 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
GOT1Aspartate aminotransferase. (413 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (146 aa)
ARG2Arginase. (354 aa)
GOT2Aspartate aminotransferase. (430 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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