STRINGSTRING
ANK1 ANK1 KDR KDR HAMP HAMP GPX3 GPX3 GPX8 GPX8 FLT1 FLT1 JAK2 JAK2 CD34 CD34 ALB ALB RHOA RHOA EPO EPO NFE2L2 NFE2L2 GPX5 GPX5 GPX6 GPX6 HMOX1 HMOX1 CNTNAP2 CNTNAP2 MB MB PRKG2 PRKG2 NFATC4 NFATC4 PPARA PPARA ESR2 ESR2 GPX2 GPX2 DLG2 DLG2 GPX7 GPX7 NOS1 NOS1 NOX4 NOX4 EGLN1 EGLN1 NOS3 NOS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANK1Ankyrin 1. (1838 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
HAMPHepcidin. (82 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (151 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1370 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
CD34CD34 molecule. (384 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
RHOARHOA. (193 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
HMOX1Heme oxygenase 1. (271 aa)
CNTNAP2Uncharacterized protein. (536 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
NFATC4Nuclear factor of activated T cells 4. (855 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner; Belongs to the nuclear hormone receptor family. NR3 subfamily. (527 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (146 aa)
DLG2Discs large MAGUK scaffold protein 2. (905 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (165 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
NOX4NADPH oxidase 4. (594 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (358 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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