STRINGSTRING
IDO2 IDO2 SOCS3 SOCS3 NLRP12 NLRP12 TLR1 TLR1 TLR6 TLR6 TRIM21 TRIM21 STAT3 STAT3 W5NUY5_SHEEP W5NUY5_SHEEP IFNG IFNG IDO1 IDO1 XBP1 XBP1 W5NYD4_SHEEP W5NYD4_SHEEP LOC101117013 LOC101117013 NLRP8 NLRP8 CALML5 CALML5 MCP-3 MCP-3 W5P415_SHEEP W5P415_SHEEP PIK3C3 PIK3C3 BCL2 BCL2 IL10 IL10 CASP3 CASP3 STAT6 STAT6 TLR3 TLR3 CD40 CD40 W5PFE8_SHEEP W5PFE8_SHEEP NMI NMI STAT2 STAT2 CASP9 CASP9 CALR CALR NLRC4 NLRC4 CALM3 CALM3 GABARAP GABARAP CD40LG CD40LG ATG5 ATG5 ATG7 ATG7 ULK1 ULK1 EGFR EGFR STAT1 STAT1 ARG1 ARG1 CCR5 CCR5 IL4 IL4 IL13 IL13 IRF1 IRF1 SOCS2 SOCS2 IL18 IL18 ATG12 ATG12 NOS2 NOS2 CASP8 CASP8 P2RX1 P2RX1 SRC SRC UBC UBC CALML4 CALML4 STAT5B STAT5B CALR3 CALR3 TRAF6 TRAF6 RIPK3 RIPK3 ATG3 ATG3 ATG16L1 ATG16L1 LRR1 LRR1 MCL1 MCL1 IL1B IL1B HIF1A HIF1A LOC105614854 LOC105614854
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IDO2Indoleamine 2,3-dioxygenase 2. (407 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
NLRP12NLR family pyrin domain containing 12. (1055 aa)
TLR1Toll-like receptor. (796 aa)
TLR6Toll-like receptor. (797 aa)
TRIM21Tripartite motif containing 21. (468 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
W5NUY5_SHEEPPeptidase S1 domain-containing protein. (188 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IDO1Indoleamine-pyrrole 2,3 dioxygenase. (410 aa)
XBP1BZIP domain-containing protein. (412 aa)
W5NYD4_SHEEPPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (256 aa)
LOC101117013Uncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
NLRP8Uncharacterized protein. (488 aa)
CALML5Calmodulin like 5. (149 aa)
MCP-3Mast cell protease 3. (264 aa)
W5P415_SHEEPPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (945 aa)
BCL2BCL2 apoptosis regulator. (139 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa)
CD40CD40 molecule. (280 aa)
W5PFE8_SHEEPPyrin domain-containing protein. (679 aa)
NMIN-myc and STAT interactor. (359 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
CALRCalreticulin. (417 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
CALM3Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (729 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1019 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
ARG1Arginase. (352 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
IL13Uncharacterized protein. (132 aa)
IRF1Interferon regulatory factor. (322 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (165 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
SRCTyrosine-protein kinase. (541 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (538 aa)
CALML4Calmodulin like 4. (197 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
CALR3Calreticulin. (384 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (501 aa)
ATG3Autophagy-related protein 3. (314 aa)
ATG16L1Autophagy related 16 like 1. (567 aa)
LRR1Leucine rich repeat protein 1. (402 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (268 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (841 aa)
LOC105614854Uncharacterized protein; Belongs to the calmodulin family. (145 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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