18 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACTG1	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	GPX5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (165 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (151 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	OTC	Ornithine carbamoyltransferase, mitochondrial. (355 aa)
	ASL	Uncharacterized protein. (468 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
	PXDN	Peroxidasin. (1368 aa)
	ARG2	Arginase. (354 aa)
	ARG1	Arginase. (352 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (146 aa)
	LYZ	Lysozyme C, kidney isozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. (148 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG1	ARG1	ENSOARP00000019868	ENSOARP00000014964	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Arginase.	0.455
ACTG1	GAPDH	ENSOARP00000019868	ENSOARP00000008476	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.936
ACTG1	GOT1	ENSOARP00000019868	ENSOARP00000013317	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Aspartate aminotransferase.	0.403
ACTG1	GOT2	ENSOARP00000019868	ENSOARP00000001804	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Aspartate aminotransferase.	0.403
ACTG1	PXDN	ENSOARP00000019868	ENSOARP00000005666	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Peroxidasin.	0.910
ARG1	ACTG1	ENSOARP00000014964	ENSOARP00000019868	Arginase.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.455
ARG1	ARG2	ENSOARP00000014964	ENSOARP00000022756	Arginase.	Arginase.	0.910
ARG1	ASL	ENSOARP00000014964	ENSOARP00000000699	Arginase.	Uncharacterized protein.	0.980
ARG1	GAPDH	ENSOARP00000014964	ENSOARP00000008476	Arginase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.663
ARG1	GOT1	ENSOARP00000014964	ENSOARP00000013317	Arginase.	Aspartate aminotransferase.	0.455
ARG1	GOT2	ENSOARP00000014964	ENSOARP00000001804	Arginase.	Aspartate aminotransferase.	0.426
ARG1	OTC	ENSOARP00000014964	ENSOARP00000000696	Arginase.	Ornithine carbamoyltransferase, mitochondrial.	0.991
ARG1	PXDN	ENSOARP00000014964	ENSOARP00000005666	Arginase.	Peroxidasin.	0.601
ARG2	ARG1	ENSOARP00000022756	ENSOARP00000014964	Arginase.	Arginase.	0.910
ARG2	ASL	ENSOARP00000022756	ENSOARP00000000699	Arginase.	Uncharacterized protein.	0.980
ARG2	GAPDH	ENSOARP00000022756	ENSOARP00000008476	Arginase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.444
ARG2	GOT1	ENSOARP00000022756	ENSOARP00000013317	Arginase.	Aspartate aminotransferase.	0.458
ARG2	GOT2	ENSOARP00000022756	ENSOARP00000001804	Arginase.	Aspartate aminotransferase.	0.419
ARG2	OTC	ENSOARP00000022756	ENSOARP00000000696	Arginase.	Ornithine carbamoyltransferase, mitochondrial.	0.991
ASL	ARG1	ENSOARP00000000699	ENSOARP00000014964	Uncharacterized protein.	Arginase.	0.980