STRINGSTRING
KLF4 KLF4 SYCP3 SYCP3 ADAM17 ADAM17 BDNF BDNF AREG AREG EREG EREG ZP2 ZP2 AMH AMH RPS6 RPS6 PTEN PTEN LATS2 LATS2 BID BID GDF9 GDF9 CASP7 CASP7 ATG7 ATG7 NPR2 NPR2 FIGLA FIGLA BRCA2 BRCA2 FOXO3 FOXO3 CCND2 CCND2 CASP9 CASP9 BMP15 BMP15 STRA8 STRA8 WNT4 WNT4 TEAD1 TEAD1 CASP3 CASP3 FOXL2 FOXL2 TAF4B TAF4B YAP1 YAP1 LIF LIF CD4 CD4 BRCA1 BRCA1 MAPK3 MAPK3 BECN1 BECN1 LATS1 LATS1 STAT3 STAT3 CDC25B CDC25B NPPC NPPC SOCS4 SOCS4 PARP1 PARP1 GJA4 GJA4 BMP4 BMP4 CYP19 CYP19 SAV1 SAV1 PDE3A PDE3A REC8 REC8 SMAD3 SMAD3 TSC2 TSC2 CASP8 CASP8 AMHR2 AMHR2 EIF4E EIF4E KITLG KITLG DAZL DAZL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF4Uncharacterized protein. (340 aa)
SYCP3Synaptonemal complex protein 3. (225 aa)
ADAM17ADAM metallopeptidase domain 17. (825 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (251 aa)
AREGAmphiregulin. (247 aa)
EREGEpiregulin. (169 aa)
ZP2Zona pellucida glycoprotein 2. (714 aa)
AMHAMH_N domain-containing protein. (213 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LATS2Large tumor suppressor kinase 2. (997 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
GDF9Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (729 aa)
NPR2Guanylate cyclase. (1066 aa)
FIGLABHLH domain-containing protein. (166 aa)
BRCA2BRCA2 DNA repair associated. (3427 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
STRA8Stimulated by retinoic acid 8. (366 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (300 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
FOXL2Fork-head domain-containing protein. (158 aa)
TAF4BTATA-box binding protein associated factor 4b. (871 aa)
YAP1Uncharacterized protein. (397 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CD4T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
BECN1Beclin 1. (448 aa)
LATS1Uncharacterized protein. (1124 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
CDC25BCell division cycle 25B. (574 aa)
NPPCC-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (92 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa)
GJA4Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (294 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
CYP19Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (424 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PDE3APhosphodiesterase. (829 aa)
REC8REC8 meiotic recombination protein. (592 aa)
SMAD3Mothers against decapentaplegic homolog. (316 aa)
TSC2TSC complex subunit 2. (1811 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (556 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
KITLGSoluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (274 aa)
DAZLDeleted in azoospermia like. (258 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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