STRINGSTRING
IL1B IL1B CD200 CD200 TRAF6 TRAF6 STAT5B STAT5B FGL2 FGL2 POMC POMC IL21 IL21 NOD2 NOD2 RELA RELA NOS2 NOS2 CXCL10 CXCL10 PPARG PPARG IL2 IL2 IL18 IL18 IGF1 IGF1 TLR2 TLR2 IL5 IL5 IL4 IL4 PTGS1 PTGS1 STAT1 STAT1 EGFR EGFR IL33 IL33 ULK1 ULK1 IGFBP3 IGFBP3 IL2RA IL2RA RCAN1 RCAN1 GDF15 GDF15 GOT1 GOT1 FLT1 FLT1 IL6 IL6 PGFS PGFS TGFB2 TGFB2 PRLR PRLR TLR7 TLR7 CD40LG CD40LG FOXO3 FOXO3 MX1 MX1 RELB RELB STAT2 STAT2 PRL PRL ITGAM ITGAM CSH CSH GHR GHR ACOX1 ACOX1 LOC101109399 LOC101109399 LOC101120448 LOC101120448 W5PEP6_SHEEP W5PEP6_SHEEP MTNR1A MTNR1A NOD1 NOD1 W5PE04_SHEEP W5PE04_SHEEP TLR3 TLR3 PGR PGR CRP CRP PTGS2 PTGS2 STAT6 STAT6 ISG15 ISG15 NR3C2 NR3C2 NR3C2-2 NR3C2-2 CD4 CD4 IL10 IL10 TLR9 TLR9 IRAK1 IRAK1 TLR4 TLR4 TLR5 TLR5 C1S C1S OXT OXT C1R C1R ABCB11 ABCB11 LOC101102413 LOC101102413 MTNR1B MTNR1B PTX3 PTX3 NLRP1 NLRP1 LEP LEP TGFB3 TGFB3 IFNG IFNG GOT2 GOT2 STAT3 STAT3 CAV1 CAV1 MYD88 MYD88 TLR6 TLR6 TLR1 TLR1 SOCS3 SOCS3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD200CD200 molecule. (299 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
FGL2Fibrinogen like 2. (441 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. (254 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
CXCL10C-X-C motif chemokine. (102 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (161 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (133 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
PTGS1Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. (593 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
IL33Interleukin 33. (274 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1019 aa)
IGFBP3Thyroglobulin type-1 domain-containing protein. (157 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (285 aa)
RCAN1Calcipressin-1; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. (197 aa)
GDF15Growth differentiation factor 15. (308 aa)
GOT1Aspartate aminotransferase. (413 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1370 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
PGFSAldo_ket_red domain-containing protein. (353 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (581 aa)
TLR7TIR domain-containing protein. (1050 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity. (656 aa)
RELBRELB proto-oncogene, NF-kB subunit. (575 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation, mammogenesis, mitogenesis and osmoregulation. (231 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
CSHChorionic somatomammotropin hormone. (239 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). (651 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (642 aa)
LOC101109399Uncharacterized protein. (210 aa)
LOC101120448Uncharacterized protein. (212 aa)
W5PEP6_SHEEPUncharacterized protein. (219 aa)
MTNR1AMelatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. (353 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (954 aa)
W5PE04_SHEEPUncharacterized protein. (229 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (347 aa)
CRPPentaxin. (224 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (607 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
ISG15Uncharacterized protein. (166 aa)
NR3C2Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity); Belongs to the nuclear hormone receptor family. NR3 subfamily. (315 aa)
NR3C2-2Uncharacterized protein. (599 aa)
CD4T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (958 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (652 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (701 aa)
OXTOxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. (107 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (719 aa)
ABCB11ATP binding cassette subfamily B member 11. (1325 aa)
LOC101102413Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
MTNR1BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
PTX3Pentraxin 3. (380 aa)
NLRP1NLR family pyrin domain containing 1. (1390 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (204 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
GOT2Aspartate aminotransferase. (430 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa)
TLR6Toll-like receptor. (797 aa)
TLR1Toll-like receptor. (796 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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