STRINGSTRING
TLR1 TLR1 HDAC10 HDAC10 CD80 CD80 CSF1 CSF1 CD200 CD200 CD47 CD47 HMOX1 HMOX1 TLR8 TLR8 W5Q4H0_SHEEP W5Q4H0_SHEEP IL18 IL18 ICAM3 ICAM3 CSF2 CSF2 ADAM17 ADAM17 IL1A IL1A CLEC12A CLEC12A ENPP1 ENPP1 CX3CR1 CX3CR1 ARG1 ARG1 STAT1 STAT1 IRF3 IRF3 IL1R2 IL1R2 CD83 CD83 ITGB2 ITGB2 IL6 IL6 TLR7 TLR7 DOK2 DOK2 ITGAM ITGAM CD40 CD40 TLR3 TLR3 STAT6 STAT6 CD4 CD4 IL10 IL10 TLR4 TLR4 TLR5 TLR5 IL34 IL34 LOC101102413 LOC101102413 TBK1 TBK1 CD163 CD163 SIGLEC1 SIGLEC1 IFNG IFNG MYD88 MYD88 TLR6 TLR6 TLR10 TLR10 TLR2 TLR2 IL13 IL13 CD68 CD68 MERTK MERTK CCR2 CCR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR1Toll-like receptor. (796 aa)
HDAC10Histone deacetylase 10. (671 aa)
CD80Uncharacterized protein. (309 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
CD200CD200 molecule. (299 aa)
CD47CD47 molecule. (291 aa)
HMOX1Heme oxygenase 1. (271 aa)
TLR8TIR domain-containing protein; Belongs to the Toll-like receptor family. (1035 aa)
W5Q4H0_SHEEPTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (606 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ICAM3Intercellular adhesion molecule 3. (534 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
ADAM17ADAM metallopeptidase domain 17. (825 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (309 aa)
CLEC12AC-type lectin domain-containing protein. (248 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (823 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
ARG1Arginase. (352 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
IRF3Interferon regulatory factor 3. (411 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
CD83CD83 molecule. (205 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (750 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
TLR7TIR domain-containing protein. (1050 aa)
DOK2Docking protein 2. (262 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
CD40CD40 molecule. (280 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CD4T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
IL34Interleukin 34. (243 aa)
LOC101102413Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
TBK1TANK binding kinase 1. (730 aa)
CD163CD163 molecule. (1136 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1701 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa)
TLR6Toll-like receptor. (797 aa)
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (812 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IL13Uncharacterized protein. (132 aa)
CD68CD68 molecule. (339 aa)
MERTKMER proto-oncogene, tyrosine kinase. (1019 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (370 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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