STRINGSTRING
IL10 IL10 S100A12 S100A12 RPS3A-2 RPS3A-2 IFNG IFNG CBX4 CBX4 ACTB ACTB W5P0I6_SHEEP W5P0I6_SHEEP RPS5 RPS5 CDK1 CDK1 LOC100037668 LOC100037668 RPL37 RPL37 ATN1 ATN1 SRGN SRGN GPX7 GPX7 RPS3A RPS3A RPL37-2 RPL37-2 RPS3A-3 RPS3A-3 TRIM25 TRIM25 ISG15 ISG15 NDC80 NDC80 RPS15A RPS15A RPS10 RPS10 RPS3 RPS3 RPS15 RPS15 RPLP0 RPLP0 IL6 IL6 STX1A STX1A RPS25 RPS25 RPL13A RPL13A RPS11 RPS11 FTH1 FTH1 RPS20 RPS20 FTH1-2 FTH1-2 RPS3A-4 RPS3A-4 AURKA AURKA ACTG1 ACTG1 SNCA SNCA MCM5 MCM5 RPLP1 RPLP1 AURKB AURKB RPS3A-5 RPS3A-5 RPS3A-6 RPS3A-6 RPS3A-7 RPS3A-7 CDC20 CDC20 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
RPS3A-240S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (242 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CBX4Chromobox 4. (510 aa)
ACTBActin, cytoplasmic 1. (378 aa)
W5P0I6_SHEEPUncharacterized protein. (69 aa)
RPS5Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
CDK1Cell division cycle 2 protein isoform 1; Belongs to the protein kinase superfamily. (297 aa)
LOC100037668Uncharacterized protein; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RPL37Ribosomal protein L37; Binds to the 23S rRNA. (97 aa)
ATN1Atrophin 1. (1168 aa)
SRGNSerglycin. (150 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (165 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPL37-2Ribosomal protein L37. (97 aa)
RPS3A-340S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
TRIM25Tripartite motif containing 25. (440 aa)
ISG15Uncharacterized protein. (166 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
RPS15ARibosomal protein S15a. (130 aa)
RPS10Ribosomal protein S10. (174 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
RPS15Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (141 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (313 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (294 aa)
RPS2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (137 aa)
RPL13AUncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (204 aa)
RPS11Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (158 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (154 aa)
RPS20Ribosomal_S10 domain-containing protein. (119 aa)
FTH1-2Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). (233 aa)
RPS3A-440S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
AURKAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
ACTG1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
SNCAGamma-synuclein; Belongs to the synuclein family. (102 aa)
MCM5DNA helicase; Belongs to the MCM family. (830 aa)
RPLP1Ribosomal protein lateral stalk subunit P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (406 aa)
RPS3A-540S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPS3A-640S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPS3A-740S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
CDC20Cell division cycle 20. (504 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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