26 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OTC	Ornithine carbamoyltransferase, mitochondrial. (355 aa)
	LOC101107259	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	LDHAL6B	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (579 aa)
	OXCT1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (520 aa)
	LDHA	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (714 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	MDH2	Malate dehydrogenase 2. (405 aa)
	ARG1	Arginase. (352 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
	LOC114118359	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (339 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (620 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (567 aa)
	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (724 aa)
	W5QFN4_SHEEP	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (518 aa)
	MDH1	Malate dehydrogenase. (352 aa)
	OXCT2	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (518 aa)
	LDHB	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (337 aa)
	ARG2	Arginase. (354 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	ACAT2	ENSOARP00000011911	ENSOARP00000004858	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
ACAT1	ACSS1	ENSOARP00000011911	ENSOARP00000007097	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-coenzyme A synthetase.	0.969
ACAT1	ACSS2	ENSOARP00000011911	ENSOARP00000011568	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase short chain family member 2.	0.958
ACAT1	IDH1	ENSOARP00000011911	ENSOARP00000020383	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Isocitrate dehydrogenase [NADP] cytoplasmic.	0.418
ACAT1	IDH2	ENSOARP00000011911	ENSOARP00000012882	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.418
ACAT1	MDH2	ENSOARP00000011911	ENSOARP00000014638	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Malate dehydrogenase 2.	0.421
ACAT1	OTC	ENSOARP00000011911	ENSOARP00000000696	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Ornithine carbamoyltransferase, mitochondrial.	0.413
ACAT1	OXCT1	ENSOARP00000011911	ENSOARP00000009587	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.976
ACAT1	OXCT2	ENSOARP00000011911	ENSOARP00000021620	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.971
ACAT1	PCK2	ENSOARP00000011911	ENSOARP00000020664	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.429
ACAT1	PKLR	ENSOARP00000011911	ENSOARP00000004524	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.542
ACAT1	W5QFN4_SHEEP	ENSOARP00000011911	ENSOARP00000021532	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.971
ACAT2	ACAT1	ENSOARP00000004858	ENSOARP00000011911	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
ACAT2	ACSS1	ENSOARP00000004858	ENSOARP00000007097	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-coenzyme A synthetase.	0.958
ACAT2	ACSS2	ENSOARP00000004858	ENSOARP00000011568	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase short chain family member 2.	0.956
ACAT2	IDH1	ENSOARP00000004858	ENSOARP00000020383	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Isocitrate dehydrogenase [NADP] cytoplasmic.	0.416
ACAT2	IDH2	ENSOARP00000004858	ENSOARP00000012882	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.415
ACAT2	LDHAL6B	ENSOARP00000004858	ENSOARP00000002913	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.405
ACAT2	LOC114118359	ENSOARP00000004858	ENSOARP00000018186	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.406
ACAT2	MDH1	ENSOARP00000004858	ENSOARP00000021549	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Malate dehydrogenase.	0.409