STRINGSTRING
TLR10 TLR10 TLR1 TLR1 IL1RAP IL1RAP SARM1 SARM1 IL1RAPL1 IL1RAPL1 TLR2 TLR2 IL1R1 IL1R1 IL1RL2 IL1RL2 IL1RL1 IL1RL1 IL18R1 IL18R1 IL18RAP IL18RAP TLR3 TLR3 TLR4 TLR4 TLR5 TLR5 MYD88 MYD88 IL1RAPL2 IL1RAPL2 TLR6 TLR6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (812 aa)
TLR1Toll-like receptor. (796 aa)
IL1RAPInterleukin 1 receptor accessory protein. (563 aa)
SARM1Sterile alpha and TIR motif containing 1. (704 aa)
IL1RAPL1Uncharacterized protein. (437 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
IL1RL2Interleukin 1 receptor like 2. (619 aa)
IL1RL1Interleukin 1 receptor like 1. (568 aa)
IL18R1Interleukin 18 receptor 1. (538 aa)
IL18RAPInterleukin 18 receptor accessory protein. (585 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa)
IL1RAPL2Interleukin 1 receptor accessory protein like 2. (429 aa)
TLR6Toll-like receptor. (797 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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