STRINGSTRING
GALM GALM W5NRG4_SHEEP W5NRG4_SHEEP W5NUH5_SHEEP W5NUH5_SHEEP AKR1A1 AKR1A1 LDHAL6B LDHAL6B HK3 HK3 G6PC G6PC G6PC2 G6PC2 ALDOA ALDOA PKLR PKLR PGAM1 PGAM1 GPI GPI ENO2 ENO2 HKDC1 HKDC1 TPI1 TPI1 HK1 HK1 ENO3 ENO3 ACSS1 ACSS1 G6PC3 G6PC3 DLD DLD ALDOB ALDOB BPGM BPGM GAPDH GAPDH FBP1 FBP1 FBP2 FBP2 PGK2 PGK2 ALDOC ALDOC ENO1 ENO1 LDHA LDHA PGM1 PGM1 PGM2 PGM2 ALDH2 ALDH2 ACSS2 ACSS2 ALDH9A1 ALDH9A1 PFKL PFKL PDHB PDHB HK2 HK2 PGAM2 PGAM2 PDHA1 PDHA1 LOC101103029 LOC101103029 LOC101111965 LOC101111965 DLAT DLAT ADH5 ADH5 GCK GCK LOC114118359 LOC114118359 PCK1 PCK1 ENO4 ENO4 ALDH3A2 ALDH3A2 ALDH7A1 ALDH7A1 PGK1 PGK1 PKM PKM ADPGK ADPGK PCK2 PCK2 PFKM PFKM LDHB LDHB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GALMAldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (342 aa)
W5NRG4_SHEEPADH_zinc_N domain-containing protein. (128 aa)
W5NUH5_SHEEPUncharacterized protein. (281 aa)
AKR1A1Aldo-keto reductase family 1 member A1. (325 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
HK3Hexokinase 3. (951 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
G6PC2Glucose-6-phosphatase catalytic subunit 2. (359 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
PGAM1Uncharacterized protein. (208 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
ENO2Enolase 2. (434 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
TPI1Triosephosphate isomerase. (214 aa)
HK1Hexokinase 1. (921 aa)
ENO3Enolase 3. (434 aa)
ACSS1Acetyl-coenzyme A synthetase. (579 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (341 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
ALDOBFructose-bisphosphate aldolase B. (364 aa)
BPGMPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
FBP1Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PGK2Phosphoglycerate kinase. (417 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (459 aa)
ENO1Enolase 1. (452 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
PGM1Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (595 aa)
PGM2Phosphoglucomutase 2; Belongs to the phosphohexose mutase family. (582 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (520 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
ALDH9A1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (469 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (752 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
HK2Hexokinase 2. (922 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
LOC101103029Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
LOC101111965PKS_ER domain-containing protein. (378 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
GCKPhosphotransferase. (465 aa)
LOC114118359L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (339 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (620 aa)
ENO4Enolase 4. (613 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
PGK1Phosphoglycerate kinase. (420 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (567 aa)
ADPGKADP dependent glucokinase. (435 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (724 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (855 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (337 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.