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| | PFAS | Uncharacterized protein. (748 aa) |
| | ADCY5-2 | Guanylate cyclase domain-containing protein. (156 aa) |
| | W5NRS0_SHEEP | PNP_UDP_1 domain-containing protein. (74 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (455 aa) |
| | NPR1 | Guanylate cyclase. (1064 aa) |
| | NME6 | Nucleoside diphosphate kinase. (188 aa) |
| | LOC101108001 | Guanylate cyclase domain-containing protein. (1535 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | NT5C2 | 5'-nucleotidase, cytosolic II. (563 aa) |
| | NME1-NME2 | Nucleoside diphosphate kinase. (268 aa) |
| | GMPS | Guanine monophosphate synthase. (705 aa) |
| | PDE6C | Phosphodiesterase. (855 aa) |
| | NTPCR | Nucleoside-triphosphatase, cancer-related. (190 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa) |
| | PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (593 aa) |
| | PDE10A | Phosphodiesterase. (791 aa) |
| | NUDT9 | ADP-ribose pyrophosphatase. (349 aa) |
| | ALLC | Allantoicase. (412 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa) |
| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | PDE2A | Phosphodiesterase. (938 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | PDE6A | Phosphodiesterase. (859 aa) |
| | W5P7K2_SHEEP | AIRC domain-containing protein. (438 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa) |
| | PDE3B | Phosphodiesterase. (1110 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (525 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (456 aa) |
| | PDE1C | Phosphodiesterase. (657 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa) |
| | ADSS1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (394 aa) |
| | GUCY1B1 | Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa) |
| | PRPS1L1 | Phosphoribosyl pyrophosphate synthetase 1 like 1. (329 aa) |
| | GUCY1A1 | Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa) |
| | ADK | Adenosine kinase. (362 aa) |
| | PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1. (665 aa) |
| | NUDT16 | U8 snoRNA-decapping enzyme; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less [...] (196 aa) |
| | NUDT2 | Nudix hydrolase 2; Belongs to the Nudix hydrolase family. (147 aa) |
| | NME7 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa) |
| | PGM1 | Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (595 aa) |
| | PGM2 | Phosphoglucomutase 2; Belongs to the phosphohexose mutase family. (582 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (606 aa) |
| | AK4 | Adenylate kinase 4; Belongs to the adenylate kinase family. (174 aa) |
| | AK9 | Adenylate kinase 9. (1909 aa) |
| | GUCY1A2 | Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (628 aa) |
| | ENPP4 | Ectonucleotide pyrophosphatase/phosphodiesterase 4. (453 aa) |
| | PDE4B | Phosphodiesterase. (544 aa) |
| | XDH | Xanthine dehydrogenase. (1329 aa) |
| | PDE9A | Phosphodiesterase. (554 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (180 aa) |
| | PRPS2 | Phosphoribosyl pyrophosphate synthetase 2. (286 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa) |
| | AK1 | Uncharacterized protein; Belongs to the adenylate kinase family. (209 aa) |
| | NPR2 | Guanylate cyclase. (1066 aa) |
| | NME4 | Nucleoside diphosphate kinase. (190 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa) |
| | DCK | Deoxycytidine kinase. (265 aa) |
| | DGUOK | Deoxyguanosine kinase. (277 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | ADCY10 | Adenylate cyclase 10. (1615 aa) |
| | HDDC3 | HD domain containing 3. (180 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (432 aa) |
| | AK5 | Adenylate kinase 5; Belongs to the adenylate kinase family. (536 aa) |
| | PDE4C | Phosphodiesterase. (794 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | ADA2 | Adenosine deaminase 2. (569 aa) |
| | PDE8A | Phosphodiesterase. (788 aa) |
| | AK3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa) |
| | APRT | Adenine phosphoribosyltransferase. (119 aa) |
| | LOC101109838 | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (330 aa) |
| | PAPSS2 | PUA_2 domain-containing protein. (427 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (902 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (823 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (343 aa) |
| | PDE7B | Phosphodiesterase. (456 aa) |
| | NUDT5 | Nudix hydrolase 5; Belongs to the Nudix hydrolase family. (221 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (353 aa) |
| | W5Q168_SHEEP | 5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (150 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | PDE5A | Phosphodiesterase. (865 aa) |
| | PDE1B | Phosphodiesterase. (535 aa) |
| | PDE4A | Phosphodiesterase. (809 aa) |
| | AK7 | Adenylate kinase 7. (723 aa) |
| | NME3 | Nucleoside diphosphate kinase. (84 aa) |
| | PDE1A | Phosphodiesterase. (514 aa) |
| | PDE8B | Phosphodiesterase. (784 aa) |
| | PDE7A | Phosphodiesterase. (457 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (492 aa) |
| | PDE11A | Phosphodiesterase. (914 aa) |
| | NT5C3B | 5'-nucleotidase, cytosolic IIIB. (454 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (434 aa) |
| | GUCY2F | Guanylate cyclase. (1108 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa) |
| | PDE6G | Phosphodiesterase 6G. (102 aa) |
| | PRPS1 | Pribosyltran_N domain-containing protein. (325 aa) |
| | PKM | Pyruvate kinase; Belongs to the pyruvate kinase family. (567 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (363 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (797 aa) |
| | ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (368 aa) |
| | PDE3A | Phosphodiesterase. (829 aa) |
| | PDE6H | Phosphodiesterase 6H. (83 aa) |
| | PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (147 aa) |
| | GUCY2C | Guanylate cyclase. (1072 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (227 aa) |
| | PRUNE1 | Prune exopolyphosphatase 1. (443 aa) |
