37 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHMT1	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
	W5NQ21_SHEEP	Amine oxidase; Belongs to the copper/topaquinone oxidase family. (136 aa)
	AGXT-2	Aminotran_5 domain-containing protein. (108 aa)
	MAOA	Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (527 aa)
	MAOB	Amine oxidase. (451 aa)
	AOC2	Amine oxidase. (747 aa)
	LOC101113086	Amine oxidase. (766 aa)
	GNMT	Glycine N-methyltransferase. (308 aa)
	PGAM1	Uncharacterized protein. (208 aa)
	PIPOX	Pipecolic acid and sarcosine oxidase. (393 aa)
	GLYCTK	Glycerate kinase. (523 aa)
	ALAS2	5-aminolevulinate synthase. (587 aa)
	ALAS1	5'-aminolevulinate synthase 1. (665 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
	SDSL	Serine dehydratase like. (329 aa)
	SDS	Serine dehydratase. (329 aa)
	BPGM	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
	PSPH	Uncharacterized protein. (231 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	GAMT	RMT2 domain-containing protein. (176 aa)
	CTH	Cystathionine gamma-lyase. (417 aa)
	PSAT1	Phosphoserine aminotransferase. (396 aa)
	PGAM2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
	AMT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (374 aa)
	GCAT	Glycine C-acetyltransferase. (430 aa)
	W5Q0R2_SHEEP	Epimerase domain-containing protein. (373 aa)
	SRR	Serine racemase. (339 aa)
	DMGDH	Dimethylglycine dehydrogenase. (907 aa)
	BHMT	Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa)
	DAO	D-amino acid oxidase. (351 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (535 aa)
	GATM	Glycine amidinotransferase. (473 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT-2	AGXT2	ENSOARP00000002779	ENSOARP00000012289	Aminotran_5 domain-containing protein.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.963
AGXT-2	ALAS1	ENSOARP00000002779	ENSOARP00000006652	Aminotran_5 domain-containing protein.	5'-aminolevulinate synthase 1.	0.914
AGXT-2	ALAS2	ENSOARP00000002779	ENSOARP00000006085	Aminotran_5 domain-containing protein.	5-aminolevulinate synthase.	0.914
AGXT-2	ALDH7A1	ENSOARP00000002779	ENSOARP00000019693	Aminotran_5 domain-containing protein.	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.	0.558
AGXT-2	AMT	ENSOARP00000002779	ENSOARP00000014768	Aminotran_5 domain-containing protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.952
AGXT-2	BHMT	ENSOARP00000002779	ENSOARP00000018515	Aminotran_5 domain-containing protein.	Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism.	0.575
AGXT-2	CBS	ENSOARP00000002779	ENSOARP00000011930	Aminotran_5 domain-containing protein.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.944
AGXT-2	DAO	ENSOARP00000002779	ENSOARP00000018732	Aminotran_5 domain-containing protein.	D-amino acid oxidase.	0.947
AGXT-2	DLD	ENSOARP00000002779	ENSOARP00000007650	Aminotran_5 domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.933
AGXT-2	DMGDH	ENSOARP00000002779	ENSOARP00000018474	Aminotran_5 domain-containing protein.	Dimethylglycine dehydrogenase.	0.446
AGXT-2	GATM	ENSOARP00000002779	ENSOARP00000022618	Aminotran_5 domain-containing protein.	Glycine amidinotransferase.	0.909
AGXT-2	GCAT	ENSOARP00000002779	ENSOARP00000015246	Aminotran_5 domain-containing protein.	Glycine C-acetyltransferase.	0.923
AGXT-2	GLDC	ENSOARP00000002779	ENSOARP00000014664	Aminotran_5 domain-containing protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.944
AGXT-2	GLYCTK	ENSOARP00000002779	ENSOARP00000006058	Aminotran_5 domain-containing protein.	Glycerate kinase.	0.853
AGXT-2	GNMT	ENSOARP00000002779	ENSOARP00000004629	Aminotran_5 domain-containing protein.	Glycine N-methyltransferase.	0.923
AGXT-2	GRHPR	ENSOARP00000002779	ENSOARP00000012311	Aminotran_5 domain-containing protein.	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.974
AGXT-2	PHGDH	ENSOARP00000002779	ENSOARP00000021923	Aminotran_5 domain-containing protein.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.710
AGXT-2	PIPOX	ENSOARP00000002779	ENSOARP00000005928	Aminotran_5 domain-containing protein.	Pipecolic acid and sarcosine oxidase.	0.947
AGXT-2	PSAT1	ENSOARP00000002779	ENSOARP00000013240	Aminotran_5 domain-containing protein.	Phosphoserine aminotransferase.	0.665
AGXT-2	PSPH	ENSOARP00000002779	ENSOARP00000010651	Aminotran_5 domain-containing protein.	Uncharacterized protein.	0.993