STRINGSTRING
W5QH04_SHEEP W5QH04_SHEEP MCCC1 MCCC1 EHHADH EHHADH HMGCS2 HMGCS2 IVD IVD OXCT2 OXCT2 BCAT1 BCAT1 W5QFN4_SHEEP W5QFN4_SHEEP HADHB HADHB HADHA HADHA ALDH7A1 ALDH7A1 ALDH3A2 ALDH3A2 W5Q8A9_SHEEP W5Q8A9_SHEEP W5Q4K3_SHEEP W5Q4K3_SHEEP HIBCH HIBCH LOC101104808 LOC101104808 AOX1 AOX1 MCEE MCEE ACSF3 ACSF3 BCAT2 BCAT2 MMUT MMUT ALDH9A1 ALDH9A1 AGXT2 AGXT2 ACAT1 ACAT1 ALDH2 ALDH2 HIBADH HIBADH ACADSB ACADSB OXCT1 OXCT1 HMGCS1 HMGCS1 HSD17B10 HSD17B10 HADH HADH PCCB PCCB AUH AUH BCKDHA BCKDHA DLD DLD HMGCL HMGCL HMGCLL1 HMGCLL1 MCCC2 MCCC2 ABAT ABAT ACAT2 ACAT2 PCCA PCCA ACAA2 ACAA2 ALDH6A1 ALDH6A1 ECHS1 ECHS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5QH04_SHEEPAmine oxidase. (518 aa)
MCCC1Methylcrotonoyl-CoA carboxylase 1. (696 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
IVDIsovaleryl-CoA dehydrogenase. (429 aa)
OXCT2Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (518 aa)
BCAT1Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (386 aa)
W5QFN4_SHEEPSuccinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (518 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
HADHAEnoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
W5Q8A9_SHEEPAcyl-CoA_dh_1 domain-containing protein. (84 aa)
W5Q4K3_SHEEPUncharacterized protein. (1345 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
LOC101104808Uncharacterized protein. (1335 aa)
AOX1Aldehyde oxidase 1. (1339 aa)
MCEEMethylmalonyl-CoA epimerase. (179 aa)
ACSF3Uncharacterized protein. (363 aa)
BCAT2Branched chain amino acid transaminase 2. (396 aa)
MMUTMethylmalonyl-CoA mutase. (755 aa)
ALDH9A1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (469 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (520 aa)
HIBADHUncharacterized protein. (330 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (434 aa)
OXCT1Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (520 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (566 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (550 aa)
AUHAU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (230 aa)
BCKDHA2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (468 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (266 aa)
MCCC2Methylcrotonoyl-CoA carboxylase 2. (563 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (646 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (536 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.