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ECHS1 ECHS1 TPH1 TPH1 DLST DLST AOC1 AOC1 IDO1 IDO1 IDO2 IDO2 MAOA MAOA MAOB MAOB CYP1A2 CYP1A2 CYP1A1 CYP1A1 ACAT2 ACAT2 AFMID AFMID TDO2 TDO2 DLD DLD AANAT-2 AANAT-2 HAAO HAAO HADH HADH KMO KMO CYP1B1 CYP1B1 W5PHB0_SHEEP W5PHB0_SHEEP KYNU KYNU GCDH GCDH ALDH2 ALDH2 ACAT1 ACAT1 ACMSD ACMSD ALDH9A1 ALDH9A1 DDC DDC TPH2 TPH2 ALDH8A1 ALDH8A1 DHTKD1 DHTKD1 KYAT3 KYAT3 W5Q1I4_SHEEP W5Q1I4_SHEEP AOX1 AOX1 LOC101104808 LOC101104808 W5Q4K3_SHEEP W5Q4K3_SHEEP ALDH3A2 ALDH3A2 ALDH7A1 ALDH7A1 CAT CAT HADHA HADHA W5QH04_SHEEP W5QH04_SHEEP EHHADH EHHADH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
TPH1Tryptophan hydroxylase 1. (450 aa)
DLSTDihydrolipoamide S-succinyltransferase. (455 aa)
AOC1Amine oxidase. (332 aa)
IDO1Indoleamine-pyrrole 2,3 dioxygenase. (410 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (407 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (527 aa)
MAOBAmine oxidase. (451 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (521 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (452 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
AANAT-2Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. Belongs to the acetyltransferase family. AANAT subfamily. (207 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (300 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (471 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
W5PHB0_SHEEPAminotran_1_2 domain-containing protein. (428 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
GCDHGlutaryl-CoA dehydrogenase. (439 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (520 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
ALDH9A1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (469 aa)
DDCDopa decarboxylase. (543 aa)
TPH2Tryptophan hydroxylase 2. (560 aa)
ALDH8A1Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (921 aa)
KYAT3Kynurenine aminotransferase 3. (457 aa)
W5Q1I4_SHEEPAminotran_1_2 domain-containing protein. (269 aa)
AOX1Aldehyde oxidase 1. (1339 aa)
LOC101104808Uncharacterized protein. (1335 aa)
W5Q4K3_SHEEPUncharacterized protein. (1345 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
HADHAEnoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
W5QH04_SHEEPAmine oxidase. (518 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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