STRINGSTRING
W5NUH5_SHEEP W5NUH5_SHEEP W5NRG4_SHEEP W5NRG4_SHEEP CYP26A1 CYP26A1 LOC101105610 LOC101105610 W5NYZ2_SHEEP W5NYZ2_SHEEP CYP1A2 CYP1A2 CYP1A1 CYP1A1 DHRS9 DHRS9 LOC101106641 LOC101106641 W5P608_SHEEP W5P608_SHEEP RDH10 RDH10 LOC105608805 LOC105608805 CYP2B6 CYP2B6 CYP2S1 CYP2S1 RDH16 RDH16 HSD17B6 HSD17B6 BCO1 BCO1 LOC101116729 LOC101116729 UGT2B7 UGT2B7 LOC101117163 LOC101117163 LOC101117764 LOC101117764 W5PHP3_SHEEP W5PHP3_SHEEP W5PHZ3_SHEEP W5PHZ3_SHEEP LOC101122788 LOC101122788 W5PIK8_SHEEP W5PIK8_SHEEP ALDH1A3 ALDH1A3 PNPLA4 PNPLA4 LOC101119393 LOC101119393 UGT2A3 UGT2A3 RDH5 RDH5 RPE65 RPE65 CYP26B1 CYP26B1 ALDH1A1 ALDH1A1 LOC101120535 LOC101120535 RDH8 RDH8 DHRS3 DHRS3 AWAT2 AWAT2 SDR16C5 SDR16C5 LOC101111965 LOC101111965 ADH5 ADH5 AOX1 AOX1 CYP27C1 CYP27C1 LOC101104808 LOC101104808 W5Q4K3_SHEEP W5Q4K3_SHEEP LRAT LRAT LOC101110727 LOC101110727 CYP3A24 CYP3A24 LOC114108597 LOC114108597 UGT1A1 UGT1A1 LOC101119050 LOC101119050 RETSAT RETSAT ALDH1A2 ALDH1A2 RDH11 RDH11 RDH12 RDH12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5NUH5_SHEEPUncharacterized protein. (281 aa)
W5NRG4_SHEEPADH_zinc_N domain-containing protein. (128 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
LOC101105610Uncharacterized protein; Belongs to the cytochrome P450 family. (515 aa)
W5NYZ2_SHEEPUncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (521 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (452 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (380 aa)
LOC101106641Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
W5P608_SHEEPUncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
LOC105608805Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa)
CYP2B6Cytochrome P450 family 2 subfamily B member 6. (454 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (488 aa)
RDH16Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
BCO1Uncharacterized protein. (595 aa)
LOC101116729UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
UGT2B7UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC101117163UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
LOC101117764UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (535 aa)
W5PHP3_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
W5PHZ3_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (520 aa)
LOC101122788UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (526 aa)
W5PIK8_SHEEPLRAT domain-containing protein. (232 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (493 aa)
PNPLA4Patatin like phospholipase domain containing 4. (258 aa)
LOC101119393UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT2A3UDP glucuronosyltransferase family 2 member A3; Belongs to the UDP-glycosyltransferase family. (556 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (304 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo. (501 aa)
LOC101120535Uncharacterized protein. (495 aa)
RDH8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (339 aa)
SDR16C5Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
LOC101111965PKS_ER domain-containing protein. (378 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
AOX1Aldehyde oxidase 1. (1339 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (480 aa)
LOC101104808Uncharacterized protein. (1335 aa)
W5Q4K3_SHEEPUncharacterized protein. (1345 aa)
LRATLRAT domain-containing protein. (229 aa)
LOC101110727Uncharacterized protein. (507 aa)
CYP3A24Cytochrome P450 3A24; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa)
LOC114108597Uncharacterized protein; Belongs to the cytochrome P450 family. (397 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (435 aa)
LOC101119050Uncharacterized protein. (279 aa)
RETSATRetinol saturase. (609 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
RDH11Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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