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RPIA RPIA HAO1 HAO1 ECHS1 ECHS1 ALDOC ALDOC IDH3A IDH3A GLUD1 GLUD1 ALDH6A1 ALDH6A1 GOT1L1 GOT1L1 DLST DLST GOT2 GOT2 OGDHL OGDHL AGXT-2 AGXT-2 HK3 HK3 ALDOA ALDOA PKLR PKLR ME3 ME3 PGAM1 PGAM1 PCCA PCCA GPI GPI ACAT2 ACAT2 ME2 ME2 ENO2 ENO2 PGD PGD HKDC1 HKDC1 TPI1 TPI1 TKTL1 TKTL1 HK1 HK1 ENO3 ENO3 GLYCTK GLYCTK TALDO1 TALDO1 IDH3B IDH3B IDH3G IDH3G ACSS1 ACSS1 DLD DLD SHMT2 SHMT2 SDSL SDSL SDS SDS ME1 ME1 ALDOB ALDOB GAPDH GAPDH PCCB PCCB ESD ESD PRPS1L1 PRPS1L1 SUCLA2 SUCLA2 FBP1 FBP1 FBP2 FBP2 PGK2 PGK2 FH FH IDNK IDNK CS CS ENO1 ENO1 PSPH PSPH SDHC SDHC SUCLG2 SUCLG2 ACSS2 ACSS2 ACAT1 ACAT1 PRPS2 PRPS2 PFKL PFKL IDH2 IDH2 MMUT MMUT PDHB PDHB PSAT1 PSAT1 GOT1 GOT1 TKFC TKFC HK2 HK2 PGAM2 PGAM2 MDH2 MDH2 GLDC GLDC AMT AMT RGN RGN PDHA1 PDHA1 ACO1 ACO1 LOC101103029 LOC101103029 OGDH OGDH SDHA SDHA DLAT DLAT ADH5 ADH5 GPT2 GPT2 MCEE MCEE GCK GCK HIBCH HIBCH PGLS PGLS TKT TKT ENO4 ENO4 PGP PGP ACO2 ACO2 MTHFR MTHFR SHMT1 SHMT1 CAT CAT HADHA HADHA PRPS1 PRPS1 PGK1 PGK1 PKM PKM ADPGK ADPGK IDH1 IDH1 RPE RPE CPS1 CPS1 PFKM PFKM MDH1 MDH1 SUCLG1 SUCLG1 HAO2 HAO2 PHGDH PHGDH EHHADH EHHADH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPIARibose 5-phosphate isomerase A. (306 aa)
HAO1Hydroxyacid oxidase 1. (377 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (459 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (536 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (461 aa)
DLSTDihydrolipoamide S-succinyltransferase. (455 aa)
GOT2Aspartate aminotransferase. (430 aa)
OGDHLOxoglutarate dehydrogenase like. (1013 aa)
AGXT-2Aminotran_5 domain-containing protein. (108 aa)
HK3Hexokinase 3. (951 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
ME3Malic enzyme. (604 aa)
PGAM1Uncharacterized protein. (208 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (646 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
ME2Malic enzyme. (584 aa)
ENO2Enolase 2. (434 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (542 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
TPI1Triosephosphate isomerase. (214 aa)
TKTL1Transketolase like 1. (622 aa)
HK1Hexokinase 1. (921 aa)
ENO3Enolase 3. (434 aa)
GLYCTKGlycerate kinase. (523 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (245 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (391 aa)
ACSS1Acetyl-coenzyme A synthetase. (579 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
SDSLSerine dehydratase like. (329 aa)
SDSSerine dehydratase. (329 aa)
ME1Malic enzyme. (545 aa)
ALDOBFructose-bisphosphate aldolase B. (364 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (550 aa)
ESDS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (292 aa)
PRPS1L1Phosphoribosyl pyrophosphate synthetase 1 like 1. (329 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (518 aa)
FBP1Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PGK2Phosphoglycerate kinase. (417 aa)
FHFumarate hydratase. (510 aa)
IDNKGluconokinase; Belongs to the gluconokinase GntK/GntV family. (185 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
ENO1Enolase 1. (452 aa)
PSPHUncharacterized protein. (231 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (432 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (286 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (752 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
MMUTMethylmalonyl-CoA mutase. (755 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PSAT1Phosphoserine aminotransferase. (396 aa)
GOT1Aspartate aminotransferase. (413 aa)
TKFCTriokinase and FMN cyclase. (571 aa)
HK2Hexokinase 2. (922 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
MDH2Malate dehydrogenase 2. (405 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (374 aa)
RGNSGL domain-containing protein. (299 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (903 aa)
LOC101103029Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
OGDHOxoglutarate dehydrogenase. (1023 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (680 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
MCEEMethylmalonyl-CoA epimerase. (179 aa)
GCKPhosphotransferase. (465 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
PGLS6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (258 aa)
TKTTransketolase. (623 aa)
ENO4Enolase 4. (613 aa)
PGPPhosphoglycolate phosphatase. (237 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (701 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
HADHAEnoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
PRPS1Pribosyltran_N domain-containing protein. (325 aa)
PGK1Phosphoglycerate kinase. (420 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (567 aa)
ADPGKADP dependent glucokinase. (435 aa)
IDH1Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (855 aa)
MDH1Malate dehydrogenase. (352 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (350 aa)
HAO2Hydroxyacid oxidase 2. (357 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (535 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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