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ALDOC ALDOC IDH3A IDH3A OTC OTC ASL ASL GOT1L1 GOT1L1 GOT2 GOT2 MTR MTR ALDOA ALDOA PKLR PKLR PGAM1 PGAM1 ASNS ASNS ENO2 ENO2 TPI1 TPI1 TKTL1 TKTL1 ENO3 ENO3 TALDO1 TALDO1 ALDH18A1 ALDH18A1 IDH3B IDH3B IDH3G IDH3G SHMT2 SHMT2 SDSL SDSL SDS SDS ALDOB ALDOB ASS1 ASS1 GAPDH GAPDH PRPS1L1 PRPS1L1 PGK2 PGK2 CS CS ENO1 ENO1 PSPH PSPH MAT1A MAT1A CBS CBS PRPS2 PRPS2 PFKL PFKL CTH CTH IDH2 IDH2 BCAT2 BCAT2 PSAT1 PSAT1 GOT1 GOT1 PGAM2 PGAM2 ARG1 ARG1 MAT2B MAT2B ACO1 ACO1 GPT2 GPT2 PAH PAH PYCR3 PYCR3 TKT TKT ENO4 ENO4 PYCR1 PYCR1 PYCR2 PYCR2 ACO2 ACO2 SHMT1 SHMT1 PRPS1 PRPS1 GLUL GLUL PGK1 PGK1 PKM PKM IDH1 IDH1 RPE RPE CPS1 CPS1 PFKM PFKM BCAT1 BCAT1 PHGDH PHGDH MAT2A MAT2A RPIA RPIA ARG2 ARG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (459 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
OTCOrnithine carbamoyltransferase, mitochondrial. (355 aa)
ASLUncharacterized protein. (468 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (461 aa)
GOT2Aspartate aminotransferase. (430 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1268 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
PGAM1Uncharacterized protein. (208 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
ENO2Enolase 2. (434 aa)
TPI1Triosephosphate isomerase. (214 aa)
TKTL1Transketolase like 1. (622 aa)
ENO3Enolase 3. (434 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (245 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (391 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
SDSLSerine dehydratase like. (329 aa)
SDSSerine dehydratase. (329 aa)
ALDOBFructose-bisphosphate aldolase B. (364 aa)
ASS1Argininosuccinate synthase 1. (410 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
PRPS1L1Phosphoribosyl pyrophosphate synthetase 1 like 1. (329 aa)
PGK2Phosphoglycerate kinase. (417 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
ENO1Enolase 1. (452 aa)
PSPHUncharacterized protein. (231 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (399 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (286 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (752 aa)
CTHCystathionine gamma-lyase. (417 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
BCAT2Branched chain amino acid transaminase 2. (396 aa)
PSAT1Phosphoserine aminotransferase. (396 aa)
GOT1Aspartate aminotransferase. (413 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
ARG1Arginase. (352 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (335 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (903 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
PAHPhenylalanine hydroxylase. (451 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (281 aa)
TKTTransketolase. (623 aa)
ENO4Enolase 4. (613 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
PYCR2Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (319 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
PRPS1Pribosyltran_N domain-containing protein. (325 aa)
GLULGlutamine synthetase. (373 aa)
PGK1Phosphoglycerate kinase. (420 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (567 aa)
IDH1Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (855 aa)
BCAT1Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (386 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (535 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
RPIARibose 5-phosphate isomerase A. (306 aa)
ARG2Arginase. (354 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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