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| | SLC8A3 | Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa) |
| | EDNRB | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (456 aa) |
| | CAMK4 | Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (333 aa) |
| | ADRA1D | Adrenoceptor alpha 1D. (564 aa) |
| | CACNA1B | Uncharacterized protein. (465 aa) |
| | CACNA1A-2 | Ion_trans domain-containing protein. (201 aa) |
| | CYSLTR1 | Cysteinyl leukotriene receptor 1. (298 aa) |
| | CHRM5 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa) |
| | PLCD1 | Phosphoinositide phospholipase C. (773 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa) |
| | MCOLN1 | Mucolipin 1. (615 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (865 aa) |
| | CHRM2 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (465 aa) |
| | CD38 | Uncharacterized protein. (45 aa) |
| | GNAL | G protein subunit alpha L. (358 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1201 aa) |
| | GRIN1 | Lig_chan-Glu_bd domain-containing protein. (226 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1063 aa) |
| | W5NWV5_SHEEP | Protein kinase domain-containing protein. (667 aa) |
| | ITPKA | Kinase; Belongs to the inositol phosphokinase (IPK) family. (99 aa) |
| | IGHM | Immunoglobulin heavy constant mu. (456 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | PDGFD | Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa) |
| | VDAC3 | Uncharacterized protein. (284 aa) |
| | CACNA1G | Ion_trans domain-containing protein. (438 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2298 aa) |
| | RYR2 | Ryanodine receptor 2. (4788 aa) |
| | GRM5 | G_PROTEIN_RECEP_F3_4 domain-containing protein. (605 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa) |
| | NOS1 | Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa) |
| | TNNC1 | Troponin C1, slow skeletal and cardiac type. (161 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. (700 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | HTR4 | 5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (402 aa) |
| | AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (372 aa) |
| | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A. (1364 aa) |
| | PTGER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (120 aa) |
| | CAMK1 | Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (307 aa) |
| | ITPKC | Kinase; Belongs to the inositol phosphokinase (IPK) family. (676 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa) |
| | PDE1C | Phosphodiesterase. (657 aa) |
| | MCU | Mitochondrial calcium uniporter. (351 aa) |
| | SPHK1 | Sphingosine kinase 1. (459 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa) |
| | PHKG2 | PHKG2; Belongs to the protein kinase superfamily. (406 aa) |
| | ATP2B3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa) |
| | SLC25A4 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa) |
| | SLC8A1 | J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (602 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (501 aa) |
| | DRD5 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (471 aa) |
| | TRDN | Uncharacterized protein. (281 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A. (469 aa) |
| | ORAI3 | ORAI calcium release-activated calcium modulator 3. (279 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2707 aa) |
| | EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) |
| | CYSLTR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (368 aa) |
| | CASQ1 | Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (294 aa) |
| | LOC105614854 | Uncharacterized protein; Belongs to the calmodulin family. (145 aa) |
| | ATP2B4 | Uncharacterized protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (478 aa) |
| | STIM2 | Stromal interaction molecule 2. (670 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1224 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | ADRA1A | Adrenoceptor alpha 1A. (432 aa) |
| | HTR6 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (434 aa) |
| | PHKG1 | Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (390 aa) |
| | ADRA1B | Adrenoceptor alpha 1B. (296 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1321 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa) |
| | CACNA1F | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1982 aa) |
| | CALM3 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | TACR3 | Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (420 aa) |
| | DRD1 | Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa) |
| | ATP2B2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1251 aa) |
| | SPHK2 | Sphingosine kinase 2. (654 aa) |
| | GRIN2C | Glutamate ionotropic receptor NMDA type subunit 2C. (917 aa) |
| | W5PRC1_SHEEP | G_PROTEIN_RECEP_F1_2 domain-containing protein. (369 aa) |
| | GNAQ | G protein subunit alpha q. (301 aa) |
| | GNA14 | G protein subunit alpha 14. (301 aa) |
| | NTSR1 | Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (416 aa) |
| | HRC | Histidine rich calcium binding protein. (730 aa) |
| | GRPR | Gastrin releasing peptide receptor. (254 aa) |
| | CACNA1S-2 | Ion_trans domain-containing protein. (95 aa) |
| | TACR1 | Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa) |
| | GNA15 | G protein subunit alpha 15. (374 aa) |
| | GNA11 | G protein subunit alpha 11. (314 aa) |
| | PTGFR | Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. (362 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa) |
| | ORAI1 | ORAI calcium release-activated calcium modulator 1. (332 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (471 aa) |
| | VDAC1 | Uncharacterized protein. (283 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1155 aa) |
| | ADRB1 | Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (430 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | MCOLN2 | Mucolipin 2. (624 aa) |
| | MCOLN3 | Mucolipin 3. (553 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (256 aa) |
| | PHKA2 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1272 aa) |
| | HRH1 | Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (489 aa) |
| | ADRB2 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (419 aa) |
| | ORAI2 | ORAI calcium release-activated calcium modulator 2. (260 aa) |
| | TRHR | Thyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (398 aa) |
| | CACNA1H | Uncharacterized protein. (891 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | P2RX4 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (385 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | CAMK1D | Calcium/calmodulin dependent protein kinase ID. (385 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa) |
| | ATP2B1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa) |
| | W5Q2B0_SHEEP | Ig-like domain-containing protein. (117 aa) |
| | MYLK3 | Myosin light chain kinase 3. (782 aa) |
| | HTR7 | 5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (450 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (387 aa) |
| | PDE1B | Phosphodiesterase. (535 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2148 aa) |
| | ATP2A2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa) |
| | PHKB | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1087 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa) |
| | PDE1A | Phosphodiesterase. (514 aa) |
| | F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa) |
| | TPCN2 | Uncharacterized protein. (721 aa) |
| | HTR2C | 5-hydroxytryptamine receptor 2C. (457 aa) |
| | P2RX5 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (451 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa) |
| | CHRM3 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa) |
| | P2RX1 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa) |
| | PHKA1 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1249 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1003 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa) |
| | CALML4 | Calmodulin like 4. (197 aa) |
| | CAMK2D | Protein kinase domain-containing protein. (533 aa) |
| | CACNA1E | Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (1858 aa) |
| | CCKBR | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (454 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1103 aa) |
| | PLCD4 | Phosphoinositide phospholipase C. (766 aa) |
| | PTAFR | Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | PPP3R1 | Uncharacterized protein. (160 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | RYR3 | Ryanodine receptor 3. (4868 aa) |
| | PLN | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa) |
| | CASQ2 | Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (431 aa) |
| | PLCZ1 | Phosphoinositide phospholipase C. (634 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (538 aa) |
