STRINGSTRING
MAPK10 MAPK10 PPP2CB PPP2CB MAP3K5 MAP3K5 PRKCZ PRKCZ PRKCG PRKCG TRAF2-2 TRAF2-2 ADORA1 ADORA1 MAPK8 MAPK8 DEGS2 DEGS2 MAPK9 MAPK9 RAC1 RAC1 PIK3R3 PIK3R3 PPP2R5C PPP2R5C SPTLC2 SPTLC2 OPRD1 OPRD1 PPP2R2B PPP2R2B CERS4 CERS4 MAPK3 MAPK3 CTSD CTSD GNA12 GNA12 PPP2R5D PPP2R5D PPP2R2C PPP2R2C PRKCE PRKCE PIK3R1 PIK3R1 AKT3 AKT3 ACER1 ACER1 SGPL1 SGPL1 PLD2 PLD2 PIK3CB PIK3CB PPP2R3C PPP2R3C HRAS HRAS SPHK1 SPHK1 S1PR3 S1PR3 FCER1A FCER1A SPTLC1 SPTLC1 PPP2R3A PPP2R3A TNF TNF SGMS2 SGMS2 ASAH1 ASAH1 ROCK1 ROCK1 PLCB1 PLCB1 ABCC1 ABCC1 PLCB4 PLCB4 CERS3 CERS3 FYN FYN FCER1G FCER1G PPP2R2A PPP2R2A GNAI2 GNAI2 S1PR1 S1PR1 PPP2R5A PPP2R5A MAP2K2 MAP2K2 SPTLC3 SPTLC3 PPP2R5B PPP2R5B SPHK2 SPHK2 GNAQ GNAQ BAX BAX NFKB1 NFKB1 MS4A2 MS4A2 MAPK14 MAPK14 MAPK13 MAPK13 BID BID ASAH2 ASAH2 RHOA RHOA SGMS1 SGMS1 PTEN PTEN ACER2 ACER2 PPP2R1B PPP2R1B PPP2R1A PPP2R1A GNA13 GNA13 MAPK1 MAPK1 S1PR2 S1PR2 TP53 TP53 RAF1 RAF1 PRKCA PRKCA NSMAF NSMAF W5Q2R1_SHEEP W5Q2R1_SHEEP BDKRB2 BDKRB2 GNAI1 GNAI1 RELA RELA RAC3 RAC3 PRKCB PRKCB CERS5 CERS5 MAP2K1 MAP2K1 PDPK1 PDPK1 GNAI3 GNAI3 ADORA3 ADORA3 KRAS KRAS NRAS NRAS SGPP2 SGPP2 KNG1 KNG1 PIK3CA PIK3CA PLD1 PLD1 CERS2 CERS2 PPP2R5E PPP2R5E SGPP1 SGPP1 TNFRSF1A TNFRSF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (426 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1224 aa)
PRKCZUncharacterized protein; Belongs to the protein kinase superfamily. (478 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
TRAF2-2MATH domain-containing protein. (215 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (419 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (290 aa)
MAPK9Mitogen-activated protein kinase. (425 aa)
RAC1Uncharacterized protein. (180 aa)
PIK3R3Uncharacterized protein. (461 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (529 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (431 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (514 aa)
CERS4Ceramide synthase 4. (393 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
CTSDCathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. (121 aa)
GNA12G protein subunit alpha 12. (383 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (596 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (266 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
PLD2Phospholipase. (1068 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
HRASHRas proto-oncogene, GTPase. (151 aa)
SPHK1Sphingosine kinase 1. (459 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (383 aa)
FCER1AHigh affinity immunoglobulin E receptor alpha subunit. (260 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (475 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (400 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ABCC1ATP binding cassette subfamily C member 1. (1523 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
CERS3Ceramide synthase 3. (334 aa)
FYNTyrosine-protein kinase. (537 aa)
FCER1GFc fragment of IgE receptor Ig. (85 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
GNAI2Uncharacterized protein. (355 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (489 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (549 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (491 aa)
SPHK2Sphingosine kinase 2. (654 aa)
GNAQG protein subunit alpha q. (301 aa)
BAXBCL2 associated X, apoptosis regulator. (194 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
ASAH2Neutral ceramidase. (770 aa)
RHOARHOA. (193 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (239 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (791 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (559 aa)
GNA13G protein subunit alpha 13. (294 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (903 aa)
W5Q2R1_SHEEPLipid_DES domain-containing protein. (323 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
GNAI1G protein subunit alpha i1. (337 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
RAC3Rac family small GTPase 3. (194 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa)
CERS5Uncharacterized protein. (381 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (559 aa)
GNAI3G protein subunit alpha i3. (317 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (317 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (343 aa)
KNG1Kininogen 1. (619 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PLD1Phospholipase. (1151 aa)
CERS2Ceramide synthase 2. (380 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (483 aa)
TNFRSF1AUncharacterized protein. (277 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.