(121 nodes) Phospholipase D signaling pathway network (Ovis aries)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGTR1	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	ADCY5-2	Guanylate cyclase domain-containing protein. (156 aa)
	AGPAT1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. (287 aa)
	ARF6	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1035 aa)
	GRM8	G_PROTEIN_RECEP_F3_4 domain-containing protein. (316 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1201 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (747 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (862 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	IGHM	Immunoglobulin heavy constant mu. (456 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	AGT	Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. (485 aa)
	SHC1	SHC adaptor protein 1. (473 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
	CYTH1	Cytohesin 1. (400 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
	AGPAT2	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (224 aa)
	GRM5	G_PROTEIN_RECEP_F3_4 domain-containing protein. (605 aa)
	F2	Uncharacterized protein; Belongs to the peptidase S1 family. (666 aa)
	AVPR1A	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
	RHEB	Uncharacterized protein. (168 aa)
	GNA12	G protein subunit alpha 12. (383 aa)
	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1125 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (372 aa)
	TSC1	TSC complex subunit 1. (1160 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	LPAR4	Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5. (292 aa)
	ARF1	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (307 aa)
	DGKE	Diacylglycerol kinase. (674 aa)
	PLD2	Phospholipase. (1068 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] (397 aa)
	GRM2	Glutamate metabotropic receptor 2. (867 aa)
	RRAS2	RAS related 2. (187 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	DGKH	Diacylglycerol kinase. (1154 aa)
	HRAS	HRas proto-oncogene, GTPase. (151 aa)
	SPHK1	Sphingosine kinase 1. (459 aa)
	MRAS	Muscle RAS oncogene homolog. (209 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa)
	LPAR2	Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	GRM7	Glutamate metabotropic receptor 7. (761 aa)
	SHC3	SHC adaptor protein 3. (426 aa)
	PLPP1	Phospholipid phosphatase 1. (285 aa)
	FCER1A	High affinity immunoglobulin E receptor alpha subunit. (260 aa)
	SYK	Tyrosine-protein kinase. (633 aa)
	PLPP3	acidPPc domain-containing protein. (312 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	DGKB	Diacylglycerol kinase. (802 aa)
	LPAR6	Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1364 aa)
	SHC2	Uncharacterized protein. (435 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1224 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
	DGKK	Diacylglycerol kinase. (1226 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (85 aa)
	DGKI	Diacylglycerol kinase. (924 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	DNM1	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (812 aa)
	DGKA	Diacylglycerol kinase. (734 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	LOC101120590	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (206 aa)
	AGPAT3	1-acylglycerol-3-phosphate O-acyltransferase 3. (378 aa)
	CYTH2	Uncharacterized protein. (422 aa)
	SPHK2	Sphingosine kinase 2. (654 aa)
	MS4A2	Membrane spanning 4-domains A2. (243 aa)
	RALB	RAS like proto-oncogene B. (228 aa)
	PIP5K1B	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (541 aa)
	PTGFR	Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. (362 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
	EGFR	Receptor protein-tyrosine kinase. (1155 aa)
	DNM3	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (451 aa)
	RHOA	RHOA. (193 aa)
	LPAR3	Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	GRM3	Glutamate metabotropic receptor 3. (879 aa)
	GNA13	G protein subunit alpha 13. (294 aa)
	MAPK1	Mitogen-activated protein kinase. (320 aa)
	KITLG	Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (274 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa)
	TSC2	TSC complex subunit 2. (1811 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	CYTH4	Cytohesin 4. (394 aa)
	DGKD	Diacylglycerol kinase. (1158 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (925 aa)
	CXCR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	CXCR1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	LPAR5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (163 aa)
	PLA2G4B	Phospholipase A2. (807 aa)
	PLA2G4E	Phospholipase A2. (799 aa)
	PLA2G4D	Phospholipase A2. (819 aa)
	PLA2G4F	Phospholipase A2. (859 aa)
	DGKG	Diacylglycerol kinase. (790 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1311 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	PLD1	Phospholipase. (1151 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
	SHC4	SHC adaptor protein 4. (630 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSOARP00000014503	ENSOARP00000015782	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.570
ADCY1	ADCY3	ENSOARP00000014503	ENSOARP00000019417	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.942
ADCY1	ADCY6	ENSOARP00000014503	ENSOARP00000020605	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.535
ADCY1	ADCY7	ENSOARP00000014503	ENSOARP00000018460	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.687
ADCY1	ADCY8	ENSOARP00000014503	ENSOARP00000008002	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.956
ADCY1	ADCY9	ENSOARP00000014503	ENSOARP00000003119	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.660
ADCY1	AKT3	ENSOARP00000014503	ENSOARP00000006511	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.910
ADCY1	PRKCA	ENSOARP00000014503	ENSOARP00000016835	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.669
ADCY1	RAPGEF3	ENSOARP00000014503	ENSOARP00000020841	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.922
ADCY1	RAPGEF4	ENSOARP00000014503	ENSOARP00000000889	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 4.	0.927
ADCY2	ADCY1	ENSOARP00000015782	ENSOARP00000014503	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.570
ADCY2	ADCY3	ENSOARP00000015782	ENSOARP00000019417	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY2	ADCY5-2	ENSOARP00000015782	ENSOARP00000000428	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein.	0.956
ADCY2	ADCY6	ENSOARP00000015782	ENSOARP00000020605	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.775
ADCY2	ADCY7	ENSOARP00000015782	ENSOARP00000018460	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.530
ADCY2	ADCY8	ENSOARP00000015782	ENSOARP00000008002	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.557
ADCY2	ADCY9	ENSOARP00000015782	ENSOARP00000003119	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.686
ADCY2	AKT3	ENSOARP00000015782	ENSOARP00000006511	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.924
ADCY2	GNA13	ENSOARP00000015782	ENSOARP00000016438	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha 13.	0.544
ADCY2	PLCB1	ENSOARP00000015782	ENSOARP00000009872	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.695