STRINGSTRING
HLA-DRA HLA-DRA W5NPE8_SHEEP W5NPE8_SHEEP THBS2-2 THBS2-2 TLR6 TLR6 ATP6V0B ATP6V0B W5NRI1_SHEEP W5NRI1_SHEEP ATP6V0E2 ATP6V0E2 M6PR M6PR W5NUD7_SHEEP W5NUD7_SHEEP DYNC1I2 DYNC1I2 ATP6V0A1 ATP6V0A1 RAC1 RAC1 DYNC1LI2 DYNC1LI2 FCAR FCAR LOC101102057 LOC101102057 TUBB6 TUBB6 ATP6V0A2 ATP6V0A2 W5NXU4_SHEEP W5NXU4_SHEEP IGHM IGHM ATP6V0D1 ATP6V0D1 DYNC1H1 DYNC1H1 CANX CANX STX12 STX12 ATP6V1F ATP6V1F CORO1A CORO1A DYNC2H1 DYNC2H1 DYNC1I1 DYNC1I1 THBS3 THBS3 RAB7A RAB7A ATP6V0E1 ATP6V0E1 NOS1 NOS1 C1R C1R ATP6AP1 ATP6AP1 RAB7B RAB7B PIK3C3 PIK3C3 SEC61A1 SEC61A1 COLEC11 COLEC11 TLR4 TLR4 ATP6V1G1 ATP6V1G1 PLA2R1 PLA2R1 LOC101108961 LOC101108961 DYA DYA LOC101115073 LOC101115073 W5PBW7_SHEEP W5PBW7_SHEEP STX18 STX18 HLA-DOB HLA-DOB TAP2 TAP2 TAP1 TAP1 LOC101109746 LOC101109746 HLA-DMA HLA-DMA HLA-DOA HLA-DOA ITGA2 ITGA2 LAMP1 LAMP1 CTSV CTSV CTSL CTSL ATP6V1G2 ATP6V1G2 ITGAM ITGAM W5PGZ6_SHEEP W5PGZ6_SHEEP TUBAL3 TUBAL3 MPO MPO W5PHX0_SHEEP W5PHX0_SHEEP MSR1 MSR1 W5PJ11_SHEEP W5PJ11_SHEEP CALR CALR W5PK06_SHEEP W5PK06_SHEEP SFTPD SFTPD FCGR3A FCGR3A W5PK77_SHEEP W5PK77_SHEEP MBLA MBLA SFTPA1 SFTPA1 ATP6V0A4 ATP6V0A4 ATP6V0C ATP6V0C W5PLN5_SHEEP W5PLN5_SHEEP RAB5B RAB5B ATP6V1B2 ATP6V1B2 NCF1 NCF1 ATP6V1B1 ATP6V1B1 TUBB TUBB ITGB3 ITGB3 MRC1 MRC1 ATP6V0D2 ATP6V0D2 CYBA CYBA RILP RILP LAMP2 LAMP2 ATP6V1E1 ATP6V1E1 MBL2 MBL2 TUBA8 TUBA8 ATP6V1H ATP6V1H LOC101107908 LOC101107908 STX7 STX7 TLR2 TLR2 ATP6V1G3 ATP6V1G3 ATP6V1C2 ATP6V1C2 OVAR-DRB1 OVAR-DRB1 W5Q266_SHEEP W5Q266_SHEEP RAB5A RAB5A EEA1 EEA1 ITGA5 ITGA5 ATP6V1E2 ATP6V1E2 DQA DQA ITGAV ITGAV ATP6V1C1 ATP6V1C1 W5Q6C9_SHEEP W5Q6C9_SHEEP LOC101114861 LOC101114861 W5Q6N3_SHEEP W5Q6N3_SHEEP THBS4 THBS4 ITGB1 ITGB1 HGS HGS SCARB1 SCARB1 ACTG1 ACTG1 RAB5C RAB5C TUBA1B TUBA1B CYBB CYBB PIKFYVE PIKFYVE W5QCK3_SHEEP W5QCK3_SHEEP NCF4 NCF4 ATP6V1A ATP6V1A TUBA4A TUBA4A LOC101116286 LOC101116286 THBS1 THBS1 ITGB5 ITGB5 TFRC TFRC SEC22B SEC22B FCGR1A FCGR1A CTSS CTSS OLR1 OLR1 CLEC7A CLEC7A ATP6V1D ATP6V1D CD14 CD14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (296 aa)
W5NPE8_SHEEPIg-like domain-containing protein. (77 aa)
THBS2-2EGF-like domain-containing protein. (191 aa)
TLR6Toll-like receptor. (797 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (211 aa)
W5NRI1_SHEEPA2M_N_2 domain-containing protein. (680 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (279 aa)
W5NUD7_SHEEPC-type lectin domain-containing protein. (375 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (632 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
RAC1Uncharacterized protein. (180 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (505 aa)
FCARFc fragment of IgA receptor. (290 aa)
LOC101102057C-type lectin domain-containing protein. (259 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (305 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
W5NXU4_SHEEPC-type lectin domain-containing protein. (357 aa)
IGHMImmunoglobulin heavy constant mu. (456 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (344 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4628 aa)
CANXCalnexin. (593 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4307 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (628 aa)
THBS3Thrombospondin 3. (952 aa)
RAB7ARAS oncogene family-like 7A. (207 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (719 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (524 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (945 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (487 aa)
COLEC11Collectin subfamily member 11. (286 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
PLA2R1Phospholipase A2 receptor 1. (1464 aa)
LOC101108961Ig-like domain-containing protein. (262 aa)
DYAIg-like domain-containing protein; Belongs to the MHC class II family. (318 aa)
LOC101115073Ig-like domain-containing protein. (267 aa)
W5PBW7_SHEEPIg-like domain-containing protein; Belongs to the MHC class I family. (320 aa)
STX18Syntaxin 18. (335 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
TAP2Uncharacterized protein. (719 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (654 aa)
LOC101109746Ig-like domain-containing protein. (267 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1171 aa)
LAMP1Lysosomal associated membrane protein 1. (392 aa)
CTSVCathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (341 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
W5PGZ6_SHEEPIg-like domain-containing protein; Belongs to the MHC class I family. (369 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
MPOMyeloperoxidase. (745 aa)
W5PHX0_SHEEPIGc1 domain-containing protein. (130 aa)
MSR1Macrophage scavenger receptor 1. (477 aa)
W5PJ11_SHEEPMHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (295 aa)
CALRCalreticulin. (417 aa)
W5PK06_SHEEPUncharacterized protein. (250 aa)
SFTPDC-type lectin domain-containing protein. (369 aa)
FCGR3AUncharacterized protein. (250 aa)
W5PK77_SHEEPC-type lectin domain-containing protein. (305 aa)
MBLAC-type lectin domain-containing protein. (248 aa)
SFTPA1Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (257 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
ATP6V0CV-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (45 aa)
W5PLN5_SHEEPV-SNARE coiled-coil homology domain-containing protein. (150 aa)
RAB5BRAB5B, member RAS oncogene family. (227 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (515 aa)
NCF1Neutrophil cytosolic factor 1. (368 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
MRC1Uncharacterized protein. (1455 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (355 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
RILPUncharacterized protein. (103 aa)
LAMP2Lysosomal associated membrane protein 2. (452 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
MBL2Mannose binding lectin 2. (249 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (493 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
LOC101107908Ig-like domain-containing protein; Belongs to the MHC class I family. (380 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
OVAR-DRB1Ig-like domain-containing protein. (165 aa)
W5Q266_SHEEPMHC_II_beta domain-containing protein. (167 aa)
RAB5AUncharacterized protein. (215 aa)
EEA1Early endosome antigen 1. (1413 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1078 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
DQAMHC class II DQA; Belongs to the MHC class II family. (255 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (426 aa)
W5Q6C9_SHEEPUncharacterized protein; Belongs to the CD36 family. (436 aa)
LOC101114861Uncharacterized protein; Belongs to the CD36 family. (472 aa)
W5Q6N3_SHEEPUncharacterized protein; Belongs to the CD36 family. (472 aa)
THBS4Thrombospondin 4. (932 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (787 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (526 aa)
ACTG1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
RAB5CUncharacterized protein. (216 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2109 aa)
W5QCK3_SHEEPIg-like domain-containing protein. (99 aa)
NCF4Neutrophil cytosolic factor 4. (341 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
LOC101116286Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
THBS1Thrombospondin 1. (1286 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
TFRCTransferrin receptor. (770 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (218 aa)
FCGR1AUncharacterized protein. (350 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (342 aa)
OLR1Oxidized low density lipoprotein receptor 1. (275 aa)
CLEC7AC-type lectin domain containing 7A. (262 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (201 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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