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| | LIN9 | Lin-9 DREAM MuvB core complex component. (698 aa) |
| | LIN52 | Lin-52 DREAM MuvB core complex component. (116 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (120 aa) |
| | LIN54 | Lin-54 DREAM MuvB core complex component. (748 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | CDC25A | Cell division cycle 25A. (527 aa) |
| | CHEK2 | Checkpoint kinase 2. (536 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa) |
| | CCND3 | Uncharacterized protein; Belongs to the cyclin family. (401 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1067 aa) |
| | VDAC3 | Uncharacterized protein. (284 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (531 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | PPID | Uncharacterized protein. (373 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (784 aa) |
| | CDK1 | Cell division cycle 2 protein isoform 1; Belongs to the protein kinase superfamily. (297 aa) |
| | RHEB | Uncharacterized protein. (168 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | SIRT1 | Sirtuin 1. (610 aa) |
| | LIN37 | Lin-37 DREAM MuvB core complex component. (246 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa) |
| | TSC1 | TSC complex subunit 1. (1160 aa) |
| | W5P6X3_SHEEP | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | FOXO1 | Fork-head domain-containing protein. (445 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2. (309 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2639 aa) |
| | RRAS2 | RAS related 2. (187 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa) |
| | MCU | Mitochondrial calcium uniporter. (351 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (151 aa) |
| | W5PBW7_SHEEP | Ig-like domain-containing protein; Belongs to the MHC class I family. (320 aa) |
| | MRAS | Muscle RAS oncogene homolog. (209 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | SLC25A4 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (501 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2707 aa) |
| | RB1 | RB transcriptional corepressor 1. (939 aa) |
| | E2F1 | E2F_TDP domain-containing protein. (180 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (294 aa) |
| | W5PGZ6_SHEEP | Ig-like domain-containing protein; Belongs to the MHC class I family. (369 aa) |
| | W5PHX0_SHEEP | IGc1 domain-containing protein. (130 aa) |
| | E2F3 | E2F transcription factor 3. (461 aa) |
| | W5PJ11_SHEEP | MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (295 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (561 aa) |
| | CCNB3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1301 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (454 aa) |
| | CALM3 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | CDK2 | Protein kinase domain-containing protein. (298 aa) |
| | FOXO3 | Fork-head domain-containing protein. (473 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (757 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (279 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (288 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IGFBP3 | Thyroglobulin type-1 domain-containing protein. (157 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (326 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (442 aa) |
| | CAPN1 | Uncharacterized protein; Belongs to the peptidase C2 family. (729 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (471 aa) |
| | CDKN1A | Uncharacterized protein. (163 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | VDAC1 | Uncharacterized protein. (283 aa) |
| | E2F5 | E2F transcription factor 5. (275 aa) |
| | LOC101103187 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | LOC101107908 | Ig-like domain-containing protein; Belongs to the MHC class I family. (380 aa) |
| | LOC105614854 | Uncharacterized protein; Belongs to the calmodulin family. (145 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (395 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1444 aa) |
| | CAPN2 | Uncharacterized protein; Belongs to the peptidase C2 family. (599 aa) |
| | SERPINE1 | SERPIN domain-containing protein; Belongs to the serpin family. (402 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2148 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (508 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1068 aa) |
| | TSC2 | TSC complex subunit 2. (1811 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1196 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | CCND1 | Cyclin_C domain-containing protein. (103 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (304 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1140 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (316 aa) |
| | CALML4 | Calmodulin like 4. (197 aa) |
| | CDK6 | Cyclin dependent kinase 6. (273 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (855 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa) |
| | PPP3R1 | Uncharacterized protein. (160 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1214 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (309 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | TRPM7 | Alpha-type protein kinase domain-containing protein. (1873 aa) |
