(69 nodes) ECM-receptor interaction network (Ovis aries)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPP1	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (279 aa)
	SV2A	Synaptic vesicle glycoprotein 2A. (744 aa)
	ITGA10	Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1670 aa)
	COL9A2	Collagen type IX alpha 2 chain. (689 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	THBS1	Thrombospondin 1. (1286 aa)
	COL2A1	Collagen type II alpha 1 chain. (1490 aa)
	FN1	Fibronectin 1. (2478 aa)
	LAMC1	Laminin subunit gamma 1. (1610 aa)
	COL6A3	Collagen type VI alpha 3 chain. (3154 aa)
	CD47	CD47 molecule. (291 aa)
	CD44	CD44 molecule (Indian blood group). (705 aa)
	ITGA11	Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1184 aa)
	COL4A6	Collagen type IV alpha 6 chain. (1706 aa)
	COL4A5	Collagen type IV alpha 5 chain. (1691 aa)
	VTN	SMB domain-containing protein. (475 aa)
	ITGB1	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
	THBS4	Thrombospondin 4. (932 aa)
	SDC1	Uncharacterized protein. (230 aa)
	W5Q6N3_SHEEP	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	LOC101114861	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	W5Q6C9_SHEEP	Uncharacterized protein; Belongs to the CD36 family. (436 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa)
	SV2C	Synaptic vesicle glycoprotein 2C. (725 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1078 aa)
	COL6A5	Collagen type VI alpha 5 chain. (2606 aa)
	COL6A6	Collagen type VI alpha 6 chain. (2265 aa)
	LAMB2	Laminin subunit beta 2. (1807 aa)
	GP9	Uncharacterized protein. (76 aa)
	TNR	Tenascin R. (1358 aa)
	HMMR	Hyaluronan mediated motility receptor. (717 aa)
	FREM1	FRAS1 related extracellular matrix 1. (2187 aa)
	DAG1	Dystroglycan 1. (900 aa)
	COL6A1	Uncharacterized protein. (1019 aa)
	COL9A3	Uncharacterized protein. (687 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (778 aa)
	COL9A1	Collagen type IX alpha 1 chain. (922 aa)
	SV2B	Synaptic vesicle glycoprotein 2B. (707 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (743 aa)
	FREM2	FRAS1 related extracellular matrix 2. (3149 aa)
	LAMA4	Laminin subunit alpha 4. (1824 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1064 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1166 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1171 aa)
	LAMA3	Laminin subunit alpha 3. (3334 aa)
	W5PC59_SHEEP	Laminin N-terminal domain-containing protein. (156 aa)
	LAMB1	Laminin subunit beta 1. (1953 aa)
	AGRN	Uncharacterized protein. (2043 aa)
	ITGB6	Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1574 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1039 aa)
	SDC4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
	DMP1	Dentin matrix acidic phosphoprotein 1. (510 aa)
	DSPP	Uncharacterized protein. (982 aa)
	COL1A1	Collagen type I alpha 1 chain. (1474 aa)
	CHAD	Chondroadherin. (358 aa)
	THBS3	Thrombospondin 3. (952 aa)
	IBSP	Integrin binding sialoprotein. (306 aa)
	GP6	Uncharacterized protein. (338 aa)
	COL1A2	Collagen type I alpha 2 chain. (1364 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1069 aa)
	LAMC2	Uncharacterized protein. (1193 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
	RELN	Uncharacterized protein. (3578 aa)
	LAMA1	Laminin subunit alpha 1. (3081 aa)
	THBS2-2	EGF-like domain-containing protein. (191 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRN	DAG1	ENSOARP00000007547	ENSOARP00000014632	Uncharacterized protein.	Dystroglycan 1.	0.989
AGRN	ITGB1	ENSOARP00000007547	ENSOARP00000018925	Uncharacterized protein.	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.524
AGRN	SDC1	ENSOARP00000007547	ENSOARP00000018418	Uncharacterized protein.	Uncharacterized protein.	0.529
AGRN	VTN	ENSOARP00000007547	ENSOARP00000019327	Uncharacterized protein.	SMB domain-containing protein.	0.471
CD44	CD47	ENSOARP00000020204	ENSOARP00000020269	CD44 molecule (Indian blood group).	CD47 molecule.	0.627
CD44	COL1A1	ENSOARP00000020204	ENSOARP00000005233	CD44 molecule (Indian blood group).	Collagen type I alpha 1 chain.	0.966
CD44	COL1A2	ENSOARP00000020204	ENSOARP00000001581	CD44 molecule (Indian blood group).	Collagen type I alpha 2 chain.	0.947
CD44	COL2A1	ENSOARP00000020204	ENSOARP00000020771	CD44 molecule (Indian blood group).	Collagen type II alpha 1 chain.	0.952
CD44	COL4A1	ENSOARP00000020204	ENSOARP00000006567	CD44 molecule (Indian blood group).	Collagen type IV alpha 1 chain.	0.908
CD44	COL4A3	ENSOARP00000020204	ENSOARP00000022057	CD44 molecule (Indian blood group).	Collagen type IV alpha 3 chain.	0.906
CD44	COL4A5	ENSOARP00000020204	ENSOARP00000019522	CD44 molecule (Indian blood group).	Collagen type IV alpha 5 chain.	0.906
CD44	COL4A6	ENSOARP00000020204	ENSOARP00000019680	CD44 molecule (Indian blood group).	Collagen type IV alpha 6 chain.	0.901
CD44	COL6A1	ENSOARP00000020204	ENSOARP00000013730	CD44 molecule (Indian blood group).	Uncharacterized protein.	0.919
CD44	COL6A3	ENSOARP00000020204	ENSOARP00000020497	CD44 molecule (Indian blood group).	Collagen type VI alpha 3 chain.	0.918
CD44	COL6A5	ENSOARP00000020204	ENSOARP00000015951	CD44 molecule (Indian blood group).	Collagen type VI alpha 5 chain.	0.903
CD44	COL6A6	ENSOARP00000020204	ENSOARP00000015805	CD44 molecule (Indian blood group).	Collagen type VI alpha 6 chain.	0.903
CD44	COL9A1	ENSOARP00000020204	ENSOARP00000012427	CD44 molecule (Indian blood group).	Collagen type IX alpha 1 chain.	0.905
CD44	COL9A2	ENSOARP00000020204	ENSOARP00000021716	CD44 molecule (Indian blood group).	Collagen type IX alpha 2 chain.	0.904
CD44	COL9A3	ENSOARP00000020204	ENSOARP00000013051	CD44 molecule (Indian blood group).	Uncharacterized protein.	0.901
CD44	FN1	ENSOARP00000020204	ENSOARP00000020765	CD44 molecule (Indian blood group).	Fibronectin 1.	0.927