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| | TLR1 | Toll-like receptor. (796 aa) |
| | TLR6 | Toll-like receptor. (797 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (425 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (377 aa) |
| | RAC1 | Uncharacterized protein. (180 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | SPP1 | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (279 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (758 aa) |
| | TBK1 | TANK binding kinase 1. (730 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (426 aa) |
| | IRF5 | Interferon regulatory factor 5. (499 aa) |
| | W5P1N4_SHEEP | C-C motif chemokine. (93 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (413 aa) |
| | LOC101114285 | C-C motif chemokine. (109 aa) |
| | LOC101114535 | C-C motif chemokine. (93 aa) |
| | LOC101111035 | C-C motif chemokine. (93 aa) |
| | LOC101111303 | C-C motif chemokine. (89 aa) |
| | LOC100101238 | C-C motif chemokine. (89 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa) |
| | TLR5 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (652 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (311 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | CD40 | CD40 molecule. (280 aa) |
| | LOC101103623 | Uncharacterized protein. (186 aa) |
| | W5PG00_SHEEP | Uncharacterized protein. (185 aa) |
| | LOC114112819 | Uncharacterized protein. (186 aa) |
| | LOC101102963 | Uncharacterized protein. (189 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | TLR7 | TIR domain-containing protein. (1050 aa) |
| | LOC105601870 | TIR domain-containing protein. (232 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (326 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | IFNAR1 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (561 aa) |
| | IFNAR2 | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1. (536 aa) |
| | IRF3 | Interferon regulatory factor 3. (411 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (721 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (475 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (376 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | CXCL9 | C-X-C motif chemokine. (125 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa) |
| | CXCL10 | C-X-C motif chemokine. (102 aa) |
| | CXCL11 | C-X-C motif chemokine. (100 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (488 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | TOLLIP | C2 domain-containing protein. (65 aa) |
| | TLR8 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1035 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (210 aa) |
| | LOC114112827 | Uncharacterized protein. (185 aa) |
| | LBP | Lipopolysaccharide binding protein. (540 aa) |
| | W5QC18_SHEEP | Uncharacterized protein. (482 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa) |
| | IRAK4 | Protein kinase domain-containing protein. (460 aa) |
| | CD80 | Uncharacterized protein. (309 aa) |
| | CD86 | Ig-like domain-containing protein. (338 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | CTSK | Cathepsin K; Belongs to the peptidase C1 family. (330 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa) |
