STRINGSTRING
ADCY5-2 ADCY5-2 PRKCG PRKCG GNGT1 GNGT1 GNG11 GNG11 LOC101108001 LOC101108001 RASD1 RASD1 FOS FOS GNB1 GNB1 GRIN1 GRIN1 GRIA4 GRIA4 MTNR1B MTNR1B ADCY9 ADCY9 GNG4 GNG4 RPS6KA5 RPS6KA5 MAPK3 MAPK3 CACNA1G CACNA1G RYR2 RYR2 NOS1 NOS1 CALML5 CALML5 GRIN2A GRIN2A GNB3 GNB3 GRIA2 GRIA2 GNGT2 GNGT2 PRKACA PRKACA CAMK2A CAMK2A ADCY8 ADCY8 GUCY1B1 GUCY1B1 KCNJ3 KCNJ3 ITPR1 ITPR1 GUCY1A1 GUCY1A1 PLCB1 PLCB1 GRIA1 GRIA1 PLCB4 PLCB4 GNAI2 GNAI2 GUCY1A2 GUCY1A2 PER3 PER3 CALM3 CALM3 GNG12 GNG12 GRIN2C GRIN2C ADCY10 ADCY10 GNAQ GNAQ KCNJ5 KCNJ5 GRIA3 GRIA3 ADCY1 ADCY1 PRKG1 PRKG1 GNG7 GNG7 PRKACB PRKACB GNG5 GNG5 GNG13 GNG13 KCNJ6 KCNJ6 CACNA1H CACNA1H ADCY2 ADCY2 MAPK1 MAPK1 PRKCA PRKCA CACNA1D CACNA1D ADCY7 ADCY7 GNAI1 GNAI1 PRKCB PRKCB ADCY3 ADCY3 CALML4 CALML4 CAMK2D CAMK2D PER2 PER2 PER1 PER1 PRKG2 PRKG2 ADCY6 ADCY6 GNAI3 GNAI3 RYR3 RYR3 GNB4 GNB4 LOC105614854 LOC105614854
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY5-2Guanylate cyclase domain-containing protein. (156 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC101108001Guanylate cyclase domain-containing protein. (1535 aa)
RASD1Ras related dexamethasone induced 1. (268 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (377 aa)
GNB1G protein subunit beta 1. (377 aa)
GRIN1Lig_chan-Glu_bd domain-containing protein. (226 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (732 aa)
MTNR1BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (908 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
CACNA1GIon_trans domain-containing protein. (438 aa)
RYR2Ryanodine receptor 2. (4788 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
CALML5Calmodulin like 5. (149 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1364 aa)
GNB3G protein subunit beta 3. (341 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (305 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2707 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
GNAI2Uncharacterized protein. (355 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (628 aa)
PER3Period circadian regulator 3. (1159 aa)
CALM3Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (917 aa)
ADCY10Adenylate cyclase 10. (1615 aa)
GNAQG protein subunit alpha q. (301 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (429 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG13G protein subunit gamma 13. (67 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
CACNA1HUncharacterized protein. (891 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2148 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa)
GNAI1G protein subunit alpha i1. (337 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
CALML4Calmodulin like 4. (197 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
PER2Period_C domain-containing protein. (281 aa)
PER1Period circadian regulator 1. (1286 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
GNAI3G protein subunit alpha i3. (317 aa)
RYR3Ryanodine receptor 3. (4868 aa)
GNB4G protein subunit beta 4. (340 aa)
LOC105614854Uncharacterized protein; Belongs to the calmodulin family. (145 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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