46 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNA13	G protein subunit alpha 13. (294 aa)
	MAPK1	Mitogen-activated protein kinase. (320 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
	GNAI1	G protein subunit alpha i1. (337 aa)
	CRH	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. (190 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	GRID2	Glutamate ionotropic receptor delta type subunit 2. (922 aa)
	PRKG2	cGMP-dependent protein kinase. (762 aa)
	GNAI3	G protein subunit alpha i3. (317 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	PLA2G4B	Phospholipase A2. (807 aa)
	PLA2G4E	Phospholipase A2. (799 aa)
	PLA2G4D	Phospholipase A2. (819 aa)
	PLA2G4F	Phospholipase A2. (859 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (279 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
	NOS1	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
	GNA12	G protein subunit alpha 12. (383 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	PPP1R17	Protein phosphatase 1 regulatory subunit 17. (161 aa)
	HRAS	HRas proto-oncogene, GTPase. (151 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2707 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
	GNAI2	Uncharacterized protein. (355 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (628 aa)
	CACNA1A-2	Ion_trans domain-containing protein. (201 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	GNAQ	G protein subunit alpha q. (301 aa)
	GNA11	G protein subunit alpha 11. (314 aa)
	ARAF	Uncharacterized protein. (612 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	PRKG1	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
	PPP2R1B	Protein phosphatase 2 scaffold subunit Abeta. (791 aa)
	LYN	Tyrosine-protein kinase. (538 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (559 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARAF	HRAS	ENSOARP00000014204	ENSOARP00000007895	Uncharacterized protein.	HRas proto-oncogene, GTPase.	0.964
ARAF	KRAS	ENSOARP00000014204	ENSOARP00000021475	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.980
ARAF	LYN	ENSOARP00000014204	ENSOARP00000015852	Uncharacterized protein.	Tyrosine-protein kinase.	0.513
ARAF	MAP2K1	ENSOARP00000014204	ENSOARP00000019518	Uncharacterized protein.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.976
ARAF	MAP2K2	ENSOARP00000014204	ENSOARP00000011562	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.973
ARAF	MAPK1	ENSOARP00000014204	ENSOARP00000016656	Uncharacterized protein.	Mitogen-activated protein kinase.	0.579
ARAF	MAPK3	ENSOARP00000014204	ENSOARP00000003967	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.605
ARAF	NRAS	ENSOARP00000014204	ENSOARP00000021503	Uncharacterized protein.	NRAS proto-oncogene, GTPase.	0.980
ARAF	PPP2CB	ENSOARP00000014204	ENSOARP00000000078	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.469
ARAF	PRKCA	ENSOARP00000014204	ENSOARP00000016835	Uncharacterized protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.911
ARAF	PRKCB	ENSOARP00000014204	ENSOARP00000018920	Uncharacterized protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.911
ARAF	PRKCG	ENSOARP00000014204	ENSOARP00000000903	Uncharacterized protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.911
ARAF	RAF1	ENSOARP00000014204	ENSOARP00000016772	Uncharacterized protein.	Raf-1 proto-oncogene, serine/threonine kinase.	0.911
CACNA1A-2	GNAI1	ENSOARP00000000523	ENSOARP00000018654	Ion_trans domain-containing protein.	G protein subunit alpha i1.	0.663
CACNA1A-2	GNAI2	ENSOARP00000000523	ENSOARP00000010904	Ion_trans domain-containing protein.	Uncharacterized protein.	0.663
CACNA1A-2	GNAI3	ENSOARP00000000523	ENSOARP00000020673	Ion_trans domain-containing protein.	G protein subunit alpha i3.	0.663
CACNA1A-2	PRKCA	ENSOARP00000000523	ENSOARP00000016835	Ion_trans domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.907
CACNA1A-2	PRKCB	ENSOARP00000000523	ENSOARP00000018920	Ion_trans domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.922
CACNA1A-2	PRKCG	ENSOARP00000000523	ENSOARP00000000903	Ion_trans domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.907
GNA11	GNAQ	ENSOARP00000014006	ENSOARP00000013278	G protein subunit alpha 11.	G protein subunit alpha q.	0.947