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| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | EDNRB | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (456 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | PRKCZ | Uncharacterized protein; Belongs to the protein kinase superfamily. (478 aa) |
| | ADCY5-2 | Guanylate cyclase domain-containing protein. (156 aa) |
| | ATF6B | Activating transcription factor 6 beta. (715 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | COL1A2 | Collagen type I alpha 2 chain. (1364 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (425 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (377 aa) |
| | GNB1 | G protein subunit beta 1. (377 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | SHC1 | SHC adaptor protein 1. (473 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (426 aa) |
| | NOS1 | Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa) |
| | RXFP1 | Relaxin family peptide receptor 1. (760 aa) |
| | MMP13 | ZnMc domain-containing protein. (489 aa) |
| | COL1A1 | Collagen type I alpha 1 chain. (1474 aa) |
| | MMP1 | Matrix metallopeptidase 1. (467 aa) |
| | GNB3 | G protein subunit beta 3. (341 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | COL4A1 | Collagen type IV alpha 1 chain. (1574 aa) |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa) |
| | RXFP4 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (358 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa) |
| | RLN3 | Relaxin 3. (136 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (151 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (311 aa) |
| | SHC3 | SHC adaptor protein 3. (426 aa) |
| | ARRB2 | Arrestin beta 2. (409 aa) |
| | MMP9 | Matrix metallopeptidase 9. (700 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (228 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1364 aa) |
| | SHC2 | Uncharacterized protein. (435 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (490 aa) |
| | GNAI2 | Uncharacterized protein. (355 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (456 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa) |
| | ARRB1 | Arrestin beta 1. (418 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | RXFP2 | Relaxin family peptide receptor 2. (754 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | RXFP3 | Relaxin family peptide receptor 3. (468 aa) |
| | VEGFD | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (328 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | GNA15 | G protein subunit alpha 15. (374 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (326 aa) |
| | W5PUC3_SHEEP | Reverse transcriptase domain-containing protein. (299 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1155 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | GNG13 | G protein subunit gamma 13. (67 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa) |
| | ACTA2 | Actin alpha 2, smooth muscle. (377 aa) |
| | INSL3 | Insulin-like protein 3. (131 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (376 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa) |
| | COL3A1 | Collagen type III alpha 1 chain. (1467 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa) |
| | ATF4 | BZIP domain-containing protein. (353 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa) |
| | GNAI1 | G protein subunit alpha i1. (337 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | SRC | Tyrosine-protein kinase. (541 aa) |
| | MMP2 | Uncharacterized protein. (621 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | COL4A5 | Collagen type IV alpha 5 chain. (1691 aa) |
| | COL4A6 | Collagen type IV alpha 6 chain. (1706 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa) |
| | GNAI3 | G protein subunit alpha i3. (317 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | COL4A3 | Collagen type IV alpha 3 chain. (1670 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1311 aa) |
| | GNB4 | G protein subunit beta 4. (340 aa) |
