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| | IRAK1 | Interleukin 1 receptor associated kinase 1. (652 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (315 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (452 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (347 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (326 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (355 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (194 aa) |
| | MRC1 | Uncharacterized protein. (1455 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa) |
| | SPHK2 | Sphingosine kinase 2. (654 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (149 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (227 aa) |
| | CALM3 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | ATP6V0C | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (45 aa) |
| | LOC101102963 | Uncharacterized protein. (189 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa) |
| | RFXAP | Regulatory factor X associated protein. (169 aa) |
| | JAK1 | Tyrosine-protein kinase. (1161 aa) |
| | FCGR3A | Uncharacterized protein. (250 aa) |
| | W5PK06_SHEEP | Uncharacterized protein. (250 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (85 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (452 aa) |
| | IL23A | Uncharacterized protein. (190 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (297 aa) |
| | ITGAM | VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa) |
| | LOC114112819 | Uncharacterized protein. (186 aa) |
| | W5PG00_SHEEP | Uncharacterized protein. (185 aa) |
| | LOC101103623 | Uncharacterized protein. (186 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (392 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa) |
| | LOC101109746 | Ig-like domain-containing protein. (267 aa) |
| | SYK | Tyrosine-protein kinase. (633 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (501 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (581 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (275 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | LOC101115073 | Ig-like domain-containing protein. (267 aa) |
| | SPHK1 | Sphingosine kinase 1. (459 aa) |
| | DYA | Ig-like domain-containing protein; Belongs to the MHC class II family. (318 aa) |
| | CD74 | CD74 molecule. (294 aa) |
| | LOC101108961 | Ig-like domain-containing protein. (262 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1464 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa) |
| | BAD | BCL2 associated agonist of cell death. (179 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa) |
| | MALT1 | MALT1 paracaspase. (764 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (945 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (524 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | W5NPE8_SHEEP | Ig-like domain-containing protein. (77 aa) |
| | RAB7A | RAS oncogene family-like 7A. (207 aa) |
| | CTSD | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. (121 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (426 aa) |
| | LSP1 | Uncharacterized protein. (196 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (344 aa) |
| | IGHM | Immunoglobulin heavy constant mu. (456 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (213 aa) |
| | LOC101102057 | C-type lectin domain-containing protein. (259 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa) |
| | CATHL2 | Cathelicidin-2; Binds to the lipid A moiety of bacterial lipipolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Potent antimicrobial activity (By similarity); Belongs to the cathelicidin family. (186 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa) |
| | CATHL3 | Cathelicidin-3; Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity); Belongs to the cathelicidin family. (190 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (425 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LOC101112427 | CAP18_C domain-containing protein. (175 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (663 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (350 aa) |
| | W5NRI1_SHEEP | A2M_N_2 domain-containing protein. (680 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (211 aa) |
| | TLR6 | Toll-like receptor. (797 aa) |
| | TLR1 | Toll-like receptor. (796 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (500 aa) |
| | NFYB | CBFD_NFYB_HMF domain-containing protein. (207 aa) |
| | W5NQH3_SHEEP | Protein kinase domain-containing protein. (188 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa) |
| | TNFRSF1A | Uncharacterized protein. (277 aa) |
| | LOC105614854 | Uncharacterized protein; Belongs to the calmodulin family. (145 aa) |
| | LOC101107359 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CLEC7A | C-type lectin domain containing 7A. (262 aa) |
| | RFX5 | Regulatory factor X5. (617 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (309 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (342 aa) |
| | FCGR1A | Uncharacterized protein. (350 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (335 aa) |
| | PPP3R1 | Uncharacterized protein. (160 aa) |
| | IRAK4 | Protein kinase domain-containing protein. (460 aa) |
| | VDR | Vitamin D receptor. (424 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa) |
| | W5QCK3_SHEEP | Ig-like domain-containing protein. (99 aa) |
| | W5QC18_SHEEP | Uncharacterized protein. (482 aa) |
| | LBP | Lipopolysaccharide binding protein. (540 aa) |
| | RAB5C | Uncharacterized protein. (216 aa) |
| | LOC114112827 | Uncharacterized protein. (185 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (210 aa) |
| | CAMK2D | Protein kinase domain-containing protein. (533 aa) |
| | CALML4 | Calmodulin like 4. (197 aa) |
| | EP300 | E1A binding protein p300. (2428 aa) |
| | SRC | Tyrosine-protein kinase. (541 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1546 aa) |
| | LOC101103784 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (488 aa) |
| | CASP10 | Uncharacterized protein. (219 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (296 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | DQA | MHC class II DQA; Belongs to the MHC class II family. (255 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | EEA1 | Early endosome antigen 1. (1413 aa) |
| | RAB5A | Uncharacterized protein. (215 aa) |
| | W5Q266_SHEEP | MHC_II_beta domain-containing protein. (167 aa) |
| | OVAR-DRB1 | Ig-like domain-containing protein. (165 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (230 aa) |
| | RHOA | RHOA. (193 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (471 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa) |
| | JAK2 | Tyrosine-protein kinase. (1133 aa) |
| | CEBPB | BZIP domain-containing protein. (126 aa) |
