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| | ARAF | Uncharacterized protein. (612 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa) |
| | ATF6B | Activating transcription factor 6 beta. (715 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (527 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | STAT3 | Signal transducer and activator of transcription. (825 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (425 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (377 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (661 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (758 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1067 aa) |
| | TBK1 | TANK binding kinase 1. (730 aa) |
| | VDAC3 | Uncharacterized protein. (284 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (426 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (413 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (784 aa) |
| | YWHAB | 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (282 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (553 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (524 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (142 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (652 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1023 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | BAD | BCL2 associated agonist of cell death. (179 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (151 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1409 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (275 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (311 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | MMP9 | Matrix metallopeptidase 9. (700 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa) |
| | RB1 | RB transcriptional corepressor 1. (939 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1364 aa) |
| | E2F1 | E2F_TDP domain-containing protein. (180 aa) |
| | LOC101103623 | Uncharacterized protein. (186 aa) |
| | W5PG00_SHEEP | Uncharacterized protein. (185 aa) |
| | LOC114112819 | Uncharacterized protein. (186 aa) |
| | STAT2 | Signal transducer and activator of transcription. (849 aa) |
| | E2F3 | E2F transcription factor 3. (461 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (452 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (490 aa) |
| | JAK1 | Tyrosine-protein kinase. (1161 aa) |
| | EGR3 | Early growth response 3. (351 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (454 aa) |
| | LOC101102963 | Uncharacterized protein. (189 aa) |
| | CDK2 | Protein kinase domain-containing protein. (298 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (456 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa) |
| | LOC105601870 | TIR domain-containing protein. (232 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1151 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (194 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | ELK1 | ETS transcription factor ELK1. (452 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (326 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa) |
| | IFNAR1 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (561 aa) |
| | IRF3 | Interferon regulatory factor 3. (411 aa) |
| | JAK2 | Tyrosine-protein kinase. (1133 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa) |
| | CDKN1A | Uncharacterized protein. (163 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (721 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | STAT1 | Signal transducer and activator of transcription. (804 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (395 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (277 aa) |
| | JAK3 | Tyrosine-protein kinase. (1091 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa) |
| | DDX58 | DExD/H-box helicase 58. (943 aa) |
| | FAS | Fas cell surface death receptor. (326 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (251 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (376 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa) |
| | ATF4 | BZIP domain-containing protein. (353 aa) |
| | CASP10 | Uncharacterized protein. (219 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (488 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (267 aa) |
| | LOC101103784 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa) |
| | SRC | Tyrosine-protein kinase. (541 aa) |
| | EP300 | E1A binding protein p300. (2428 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (316 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (210 aa) |
| | LOC114112827 | Uncharacterized protein. (185 aa) |
| | YWHAZ | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). (247 aa) |
| | STAT5B | Signal transducer and activator of transcription. (791 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (855 aa) |
| | IRAK4 | Protein kinase domain-containing protein. (460 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1311 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | SLC10A1 | Solute carrier family 10 member 1. (370 aa) |
| | LOC101107359 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
