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| | JAK1 | Tyrosine-protein kinase. (1161 aa) |
| | W5NPE8_SHEEP | Ig-like domain-containing protein. (77 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | ADCY5-2 | Guanylate cyclase domain-containing protein. (156 aa) |
| | NFYB | CBFD_NFYB_HMF domain-containing protein. (207 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (877 aa) |
| | ATF6B | Activating transcription factor 6 beta. (715 aa) |
| | BCL2L1 | Bcl-x long protein. (233 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (425 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (377 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | MAD1L1 | Uncharacterized protein. (208 aa) |
| | CHEK2 | Checkpoint kinase 2. (536 aa) |
| | CCND3 | Uncharacterized protein; Belongs to the cyclin family. (401 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | CANX | Calnexin. (593 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (758 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (318 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1067 aa) |
| | VDAC3 | Uncharacterized protein. (284 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (426 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (413 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) |
| | ELK4 | ETS transcription factor ELK4. (468 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (784 aa) |
| | MSX2 | Msh homeobox 2. (188 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (553 aa) |
| | TBP | Uncharacterized protein. (315 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa) |
| | SRF | Serum response factor. (353 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | ZFP36 | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compo [...] (324 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MMP7 | ZnMc domain-containing protein. (276 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2639 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. (527 aa) |
| | ITGAL | VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1164 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (817 aa) |
| | LOC101108961 | Ig-like domain-containing protein. (262 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa) |
| | DYA | Ig-like domain-containing protein; Belongs to the MHC class II family. (318 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (151 aa) |
| | LOC101115073 | Ig-like domain-containing protein. (267 aa) |
| | W5PBW7_SHEEP | Ig-like domain-containing protein; Belongs to the MHC class I family. (320 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1409 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (311 aa) |
| | SLC25A4 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (501 aa) |
| | LOC101109746 | Ig-like domain-containing protein. (267 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | RB1 | RB transcriptional corepressor 1. (939 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | CD40 | CD40 molecule. (280 aa) |
| | LTA | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa) |
| | E2F1 | E2F_TDP domain-containing protein. (180 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (294 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | W5PGZ6_SHEEP | Ig-like domain-containing protein; Belongs to the MHC class I family. (369 aa) |
| | CD3D | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (167 aa) |
| | CD3G | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (200 aa) |
| | W5PHX0_SHEEP | IGc1 domain-containing protein. (130 aa) |
| | BUB3 | WD_REPEATS_REGION domain-containing protein. (328 aa) |
| | E2F3 | E2F transcription factor 3. (461 aa) |
| | W5PJ11_SHEEP | MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (295 aa) |
| | CALR | Calreticulin. (417 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (490 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (454 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (953 aa) |
| | CDK2 | Protein kinase domain-containing protein. (298 aa) |
| | RAN-2 | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (456 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | CDC27 | Cell division cycle 27. (826 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | TLN1 | Talin 1. (2542 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (161 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (194 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IL15RA | Sushi domain-containing protein. (277 aa) |
| | ELK1 | ETS transcription factor ELK1. (452 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (285 aa) |
| | CRTC3 | CREB regulated transcription coactivator 3. (595 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (442 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (573 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (398 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (657 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa) |
| | PTTG1 | Uncharacterized protein. (202 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (471 aa) |
| | CDKN1A | Uncharacterized protein. (163 aa) |
| | VDAC1 | Uncharacterized protein. (283 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (721 aa) |
| | LOC101107908 | Ig-like domain-containing protein; Belongs to the MHC class I family. (380 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (395 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1943 aa) |
| | ETS2 | ETS proto-oncogene 2, transcription factor. (466 aa) |
| | JAK3 | Tyrosine-protein kinase. (1091 aa) |
| | TBPL1 | TATA-box binding protein like 1. (188 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (757 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (376 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa) |
| | OVAR-DRB1 | Ig-like domain-containing protein. (165 aa) |
| | ICAM1 | Ig-like domain-containing protein. (536 aa) |
| | W5Q266_SHEEP | MHC_II_beta domain-containing protein. (167 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (211 aa) |
| | W5Q2B0_SHEEP | Ig-like domain-containing protein. (117 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (747 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (405 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa) |
| | DQA | MHC class II DQA; Belongs to the MHC class II family. (255 aa) |
| | EGR1 | DUF3446 domain-containing protein. (298 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2111 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (296 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (600 aa) |
| | ATF4 | BZIP domain-containing protein. (353 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | CCND1 | Cyclin_C domain-containing protein. (103 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (924 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (543 aa) |
| | ANAPC11 | RING-type domain-containing protein. (84 aa) |
| | EP300 | E1A binding protein p300. (2428 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (316 aa) |
| | RANBP1 | RAN binding protein 1. (200 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (815 aa) |
| | STAT5B | Signal transducer and activator of transcription. (791 aa) |
| | W5QCK3_SHEEP | Ig-like domain-containing protein. (99 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (855 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa) |
| | PPP3R1 | Uncharacterized protein. (160 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | BUB1B | Uncharacterized protein. (1062 aa) |
| | ANAPC2-2 | Uncharacterized protein. (185 aa) |
| | XPO1 | Exportin 1. (1072 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (492 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | TLN2 | Talin 2. (2557 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | TNFRSF1A | Uncharacterized protein. (277 aa) |
