STRINGSTRING
CYP3A24 CYP3A24 CYP2E1 CYP2E1 W5NRG4_SHEEP W5NRG4_SHEEP W5NSD7_SHEEP W5NSD7_SHEEP W5NUH5_SHEEP W5NUH5_SHEEP CYP1A2 CYP1A2 LOC101114075 LOC101114075 CYP1A1 CYP1A1 LOC101120889 LOC101120889 LOC101106641 LOC101106641 W5P608_SHEEP W5P608_SHEEP CYP2A6 CYP2A6 LOC105608805 LOC105608805 CYP2B6 CYP2B6 LOC101116273 LOC101116273 HSD11B1L HSD11B1L GSTO2 GSTO2 PTGS2 PTGS2 LOC101116729 LOC101116729 UGT2B7 UGT2B7 LOC101117163 LOC101117163 LOC101117764 LOC101117764 CYP1B1 CYP1B1 W5PHB0_SHEEP W5PHB0_SHEEP W5PHP3_SHEEP W5PHP3_SHEEP W5PHZ3_SHEEP W5PHZ3_SHEEP LOC101122788 LOC101122788 LOC101119393 LOC101119393 UGT2A3 UGT2A3 SULT2A1 SULT2A1 MGST3 MGST3 GSTP1 GSTP1 MGST2 MGST2 HSD11B1 HSD11B1 W5PUH4_SHEEP W5PUH4_SHEEP LOC101120535 LOC101120535 GSTT4 GSTT4 W5PVN0_SHEEP W5PVN0_SHEEP LOC101118990 LOC101118990 LOC101114408 LOC101114408 LOC101115172 LOC101115172 GSTA1-1 GSTA1-1 LOC101106720 LOC101106720 LOC101106976 LOC101106976 KYAT3 KYAT3 GSTA4 GSTA4 LOC101111965 LOC101111965 ADH5 ADH5 EPHX1 EPHX1 GSTA1 GSTA1 GSTK1 GSTK1 HPGDS HPGDS LOC101110727 LOC101110727 LOC114108597 LOC114108597 UGT1A1 UGT1A1 LOC101107401 LOC101107401 W5QDB7_SHEEP W5QDB7_SHEEP LOC101108092 LOC101108092 GSTM3 GSTM3 MGST1 MGST1 ARNT ARNT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP3A24Cytochrome P450 3A24; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa)
CYP2E1Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
W5NRG4_SHEEPADH_zinc_N domain-containing protein. (128 aa)
W5NSD7_SHEEPUncharacterized protein. (241 aa)
W5NUH5_SHEEPUncharacterized protein. (281 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (521 aa)
LOC101114075Sulfotransferase; Belongs to the sulfotransferase 1 family. (302 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (452 aa)
LOC101120889Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
LOC101106641Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
W5P608_SHEEPUncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
CYP2A6Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
LOC105608805Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa)
CYP2B6Cytochrome P450 family 2 subfamily B member 6. (454 aa)
LOC101116273Uncharacterized protein. (241 aa)
HSD11B1LHydroxysteroid 11-beta dehydrogenase 1 like. (292 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (607 aa)
LOC101116729UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
UGT2B7UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC101117163UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
LOC101117764UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (535 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
W5PHB0_SHEEPAminotran_1_2 domain-containing protein. (428 aa)
W5PHP3_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
W5PHZ3_SHEEPUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (520 aa)
LOC101122788UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (526 aa)
LOC101119393UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT2A3UDP glucuronosyltransferase family 2 member A3; Belongs to the UDP-glycosyltransferase family. (556 aa)
SULT2A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
GSTP1Uncharacterized protein; Belongs to the GST superfamily. (209 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. (292 aa)
W5PUH4_SHEEPUncharacterized protein; Belongs to the GST superfamily. (214 aa)
LOC101120535Uncharacterized protein. (495 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (168 aa)
W5PVN0_SHEEPUncharacterized protein; Belongs to the GST superfamily. (211 aa)
LOC101118990Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
LOC101114408Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
LOC101115172Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (291 aa)
GSTA1-1Uncharacterized protein. (223 aa)
LOC101106720Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
LOC101106976Uncharacterized protein. (227 aa)
KYAT3Kynurenine aminotransferase 3. (457 aa)
GSTA4Glutathione S-transferase alpha 4. (238 aa)
LOC101111965PKS_ER domain-containing protein. (378 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (451 aa)
GSTA1Uncharacterized protein. (222 aa)
GSTK1Glutathione S-transferase kappa. (226 aa)
HPGDSHematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (201 aa)
LOC101110727Uncharacterized protein. (507 aa)
LOC114108597Uncharacterized protein; Belongs to the cytochrome P450 family. (397 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (435 aa)
LOC101107401Uncharacterized protein. (221 aa)
W5QDB7_SHEEPUncharacterized protein. (229 aa)
LOC101108092Uncharacterized protein; Belongs to the GST superfamily. (229 aa)
GSTM3Glutathione S-transferase. (230 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
ARNTAryl-hydrocarbon receptor nuclear translocator. (790 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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