STRINGSTRING
PDGFRB PDGFRB PDGFC PDGFC PIK3CB PIK3CB HRAS HRAS GADD45G GADD45G RB1 RB1 FGF10 FGF10 E2F1 E2F1 FGF22 FGF22 FGF20 FGF20 E2F3 E2F3 MITF MITF BAK1 BAK1 FGF6 FGF6 FGF17 FGF17 MAP2K2 MAP2K2 GADD45A GADD45A FGF21 FGF21 BAX BAX ARAF ARAF CDKN1A CDKN1A GADD45B GADD45B EGFR EGFR LOC101103187 LOC101103187 PTEN PTEN MAPK1 MAPK1 TP53 TP53 RAF1 RAF1 IGF1 IGF1 FGFR1 FGFR1 FGF1 FGF1 PIK3R3 PIK3R3 PDGFD PDGFD CDH1 CDH1 FGF18 FGF18 MAPK3 MAPK3 CDK4 CDK4 DDB2 DDB2 PIK3R1 PIK3R1 MET MET AKT3 AKT3 FGF7 FGF7 PIK3CA PIK3CA NRAS NRAS KRAS KRAS PDGFRA PDGFRA CDK6 CDK6 MAP2K1 MAP2K1 FGF19 FGF19 CCND1 CCND1 FGF8 FGF8 POLK POLK HGF HGF BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (307 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
HRASHRas proto-oncogene, GTPase. (151 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RB1RB transcriptional corepressor 1. (939 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
E2F1E2F_TDP domain-containing protein. (180 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (297 aa)
E2F3E2F transcription factor 3. (461 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (348 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
BAXBCL2 associated X, apoptosis regulator. (194 aa)
ARAFUncharacterized protein. (612 aa)
CDKN1AUncharacterized protein. (163 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
LOC101103187E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
FGFR1Fibroblast growth factor receptor. (788 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa)
PIK3R3Uncharacterized protein. (461 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1384 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FGF7Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity); Belongs to the heparin-binding growth factors family. (194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
CDK6Cyclin dependent kinase 6. (273 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (137 aa)
CCND1Cyclin_C domain-containing protein. (103 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
POLKDNA polymerase kappa. (873 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (734 aa)
BADBCL2 associated agonist of cell death. (179 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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