STRINGSTRING
PRKCG PRKCG PIK3CA PIK3CA SOS2 SOS2 NRAS NRAS KRAS KRAS ALK ALK STAT5B STAT5B PDPK1 PDPK1 CDK6 CDK6 MAP2K1 MAP2K1 PRKCB PRKCB CCND1 CCND1 POLK POLK HGF HGF RASSF1 RASSF1 PRKCA PRKCA RAF1 RAF1 TP53 TP53 MAPK1 MAPK1 JAK3 JAK3 EGFR EGFR GADD45B GADD45B CDKN1A CDKN1A ARAF ARAF BAX BAX ERBB2 ERBB2 RXRG RXRG GADD45A GADD45A MAP2K2 MAP2K2 FOXO3 FOXO3 BAK1 BAK1 CASP9 CASP9 E2F3 E2F3 PLCG2 PLCG2 E2F1 E2F1 SOS1 SOS1 RB1 RB1 GADD45G GADD45G EML4 EML4 HRAS HRAS PIK3CB PIK3CB BAD BAD AKT3 AKT3 PIK3R1 PIK3R1 DDB2 DDB2 CDK4 CDK4 STK4 STK4 RARB RARB MAPK3 MAPK3 PIK3R3 PIK3R3 PLCG1 PLCG1 STAT3 STAT3 MET MET
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1311 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ALKTyrosine-protein kinase receptor. (1012 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (559 aa)
CDK6Cyclin dependent kinase 6. (273 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa)
CCND1Cyclin_C domain-containing protein. (103 aa)
POLKDNA polymerase kappa. (873 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (734 aa)
RASSF1Uncharacterized protein. (268 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
JAK3Tyrosine-protein kinase. (1091 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CDKN1AUncharacterized protein. (163 aa)
ARAFUncharacterized protein. (612 aa)
BAXBCL2 associated X, apoptosis regulator. (194 aa)
ERBB2Receptor protein-tyrosine kinase. (1251 aa)
RXRGRetinoid X receptor gamma. (463 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
E2F3E2F transcription factor 3. (461 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1224 aa)
E2F1E2F_TDP domain-containing protein. (180 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1364 aa)
RB1RB transcriptional corepressor 1. (939 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
EML4EMAP like 4. (995 aa)
HRASHRas proto-oncogene, GTPase. (151 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
BADBCL2 associated agonist of cell death. (179 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa)
STK4Serine/threonine kinase 4. (488 aa)
RARBRetinoic acid receptor beta. (448 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
PIK3R3Uncharacterized protein. (461 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1201 aa)
STAT3Signal transducer and activator of transcription. (825 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1384 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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