STRINGSTRING
ITGA9 ITGA9 TPM4 TPM4 CACNG7 CACNG7 ITGA6 ITGA6 PRKAB1 PRKAB1 TNNI3 TNNI3 TPM3 TPM3 TGFB3 TGFB3 ATP2A1 ATP2A1 AGT AGT RYR2 RYR2 TNNC1 TNNC1 PRKAG2 PRKAG2 EMD EMD SGCA SGCA ITGA3 ITGA3 ITGB6 ITGB6 MYL3 MYL3 TGFB1 TGFB1 LAMA1 LAMA1 SLC8A1 SLC8A1 PRKAA2 PRKAA2 ITGA2 ITGA2 ITGA1 ITGA1 TNF TNF ITGA8 ITGA8 CACNB4 CACNB4 CACNA2D2 CACNA2D2 PRKAA1 PRKAA1 ITGB8 ITGB8 SGCD SGCD CACNA1F CACNA1F TGFB2 TGFB2 ITGB3 ITGB3 TPM2 TPM2 IL6 IL6 CACNA1S-2 CACNA1S-2 CACNA2D4 CACNA2D4 CACNB2 CACNB2 ACE ACE W5PU85_SHEEP W5PU85_SHEEP SGCG SGCG DAG1 DAG1 CACNA2D3 CACNA2D3 CACNG4 CACNG4 CACNG1 CACNG1 IGF1 IGF1 ITGA5 ITGA5 CACNA1D CACNA1D ATP2A2 ATP2A2 CACNA2D1 CACNA2D1 ITGAV ITGAV ITGB7 ITGB7 ITGA4 ITGA4 TTN TTN ITGB1 ITGB1 CACNG3 CACNG3 MYL2 MYL2 ATP2A3 ATP2A3 SGCB SGCB ITGA11 ITGA11 ACTG1 ACTG1 CACNG2 CACNG2 PRKAG1 PRKAG1 MYH7 MYH7 PRKAG3 PRKAG3 DES DES ITGB5 ITGB5 PRKAB2 PRKAB2 ITGA10 ITGA10 TPM1 TPM1 SLC8A3 SLC8A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (194 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1069 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
TNNI3Troponin I3, cardiac type. (212 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (285 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1063 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. (485 aa)
RYR2Ryanodine receptor 2. (4788 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (324 aa)
EMDEmerin. (206 aa)
SGCASarcoglycan alpha. (389 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1039 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
MYL3Myosin light chain 3. (199 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
LAMA1Laminin subunit alpha 1. (3081 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (602 aa)
PRKAA2Non-specific serine/threonine protein kinase. (546 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1171 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1064 aa)
CACNB4SH3 domain-containing protein. (501 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (963 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (743 aa)
SGCDSarcoglycan delta. (289 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1982 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
TPM2Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
CACNA1S-2Ion_trans domain-containing protein. (95 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1089 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (613 aa)
ACEAngiotensin-converting enzyme. (1206 aa)
W5PU85_SHEEPAngiotensin-converting enzyme. (624 aa)
SGCGSarcoglycan gamma. (291 aa)
DAG1Dystroglycan 1. (900 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (915 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (269 aa)
CACNG1Calcium voltage-gated channel auxiliary subunit gamma 1. (149 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1078 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2148 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1071 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa)
TTNTitin. (32000 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
MYL2Myosin light chain 2. (166 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1003 aa)
SGCBSarcoglycan beta. (319 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1184 aa)
ACTG1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PRKAG3Uncharacterized protein. (523 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (271 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (294 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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