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EIF4G1 EIF4G1 W5NPE8_SHEEP W5NPE8_SHEEP LAMA1 LAMA1 CAV1 CAV1 RAC1 RAC1 IGHM IGHM SGCA SGCA PRF1 PRF1 ITGAL ITGAL LOC101108961 LOC101108961 DYA DYA LOC101115073 LOC101115073 W5PBW7_SHEEP W5PBW7_SHEEP HLA-DOB HLA-DOB CASP3 CASP3 LOC101109746 LOC101109746 HLA-DMA HLA-DMA CD55 CD55 HLA-DOA HLA-DOA CD40 CD40 EIF4G3 EIF4G3 W5PGZ6_SHEEP W5PGZ6_SHEEP W5PHX0_SHEEP W5PHX0_SHEEP CASP9 CASP9 W5PJ11_SHEEP W5PJ11_SHEEP FYN FYN EIF4G2 EIF4G2 SGCD SGCD CD40LG CD40LG SGCG SGCG BID BID DAG1 DAG1 LOC101107908 LOC101107908 OVAR-DRB1 OVAR-DRB1 ICAM1 ICAM1 W5Q266_SHEEP W5Q266_SHEEP W5Q2B0_SHEEP W5Q2B0_SHEEP CXADR CXADR DQA DQA ABL2 ABL2 HLA-DRA HLA-DRA CASP8 CASP8 LOC101103784 LOC101103784 RAC3 RAC3 CCND1 CCND1 CD28 CD28 SGCB SGCB ACTG1 ACTG1 W5QCK3_SHEEP W5QCK3_SHEEP MYH7 MYH7 CD80 CD80 CD86 CD86 LOC101107359 LOC101107359
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1629 aa)
W5NPE8_SHEEPIg-like domain-containing protein. (77 aa)
LAMA1Laminin subunit alpha 1. (3081 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
RAC1Uncharacterized protein. (180 aa)
IGHMImmunoglobulin heavy constant mu. (456 aa)
SGCASarcoglycan alpha. (389 aa)
PRF1Perforin 1. (549 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1164 aa)
LOC101108961Ig-like domain-containing protein. (262 aa)
DYAIg-like domain-containing protein; Belongs to the MHC class II family. (318 aa)
LOC101115073Ig-like domain-containing protein. (267 aa)
W5PBW7_SHEEPIg-like domain-containing protein; Belongs to the MHC class I family. (320 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
LOC101109746Ig-like domain-containing protein. (267 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
CD55Uncharacterized protein. (547 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
CD40CD40 molecule. (280 aa)
EIF4G3Eukaryotic translation initiation factor 4 gamma 3. (1614 aa)
W5PGZ6_SHEEPIg-like domain-containing protein; Belongs to the MHC class I family. (369 aa)
W5PHX0_SHEEPIGc1 domain-containing protein. (130 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
W5PJ11_SHEEPMHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (295 aa)
FYNTyrosine-protein kinase. (537 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (941 aa)
SGCDSarcoglycan delta. (289 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
SGCGSarcoglycan gamma. (291 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
DAG1Dystroglycan 1. (900 aa)
LOC101107908Ig-like domain-containing protein; Belongs to the MHC class I family. (380 aa)
OVAR-DRB1Ig-like domain-containing protein. (165 aa)
ICAM1Ig-like domain-containing protein. (536 aa)
W5Q266_SHEEPMHC_II_beta domain-containing protein. (167 aa)
W5Q2B0_SHEEPIg-like domain-containing protein. (117 aa)
CXADRUncharacterized protein. (365 aa)
DQAMHC class II DQA; Belongs to the MHC class II family. (255 aa)
ABL2Tyrosine-protein kinase. (1110 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (296 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
LOC101103784Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RAC3Rac family small GTPase 3. (194 aa)
CCND1Cyclin_C domain-containing protein. (103 aa)
CD28IGv domain-containing protein. (265 aa)
SGCBSarcoglycan beta. (319 aa)
ACTG1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
W5QCK3_SHEEPIg-like domain-containing protein. (99 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CD80Uncharacterized protein. (309 aa)
CD86Ig-like domain-containing protein. (338 aa)
LOC101107359Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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