(10 nodes) Mixed, incl. Hyaluronidase, and Link domain network (Oryctolagus cuniculus)

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second shell of interactors

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Known Interactions

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Your Input:
	MMP13	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (931 aa)
	SOX9	SRY-box transcription factor 9. (496 aa)
	RUNX2	RUNX family transcription factor 2. (343 aa)
	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif 4. (851 aa)
	COL2A1	Fibrillar collagen NC1 domain-containing protein. (1487 aa)
	HYAL4	Hyaluronidase. (484 aa)
	HYAL3	Hyaluronidase. (492 aa)
	ACAN	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2167 aa)
	BCAN	Brevican. (736 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS4	ENSOCUP00000024918	ENSOCUP00000011609	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.963
ACAN	ADAMTS5	ENSOCUP00000024918	ENSOCUP00000002482	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.950
ACAN	BCAN	ENSOCUP00000024918	ENSOCUP00000025883	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Brevican.	0.896
ACAN	COL2A1	ENSOCUP00000024918	ENSOCUP00000011756	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibrillar collagen NC1 domain-containing protein.	0.958
ACAN	HYAL3	ENSOCUP00000024918	ENSOCUP00000017267	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronidase.	0.779
ACAN	HYAL4	ENSOCUP00000024918	ENSOCUP00000012986	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronidase.	0.777
ACAN	MMP13	ENSOCUP00000024918	ENSOCUP00000002145	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.936
ACAN	RUNX2	ENSOCUP00000024918	ENSOCUP00000010093	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	RUNX family transcription factor 2.	0.851
ACAN	SOX9	ENSOCUP00000024918	ENSOCUP00000010009	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	SRY-box transcription factor 9.	0.921
ADAMTS4	ACAN	ENSOCUP00000011609	ENSOCUP00000024918	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.963
ADAMTS4	BCAN	ENSOCUP00000011609	ENSOCUP00000025883	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Brevican.	0.907
ADAMTS4	COL2A1	ENSOCUP00000011609	ENSOCUP00000011756	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Fibrillar collagen NC1 domain-containing protein.	0.785
ADAMTS4	HYAL3	ENSOCUP00000011609	ENSOCUP00000017267	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Hyaluronidase.	0.465
ADAMTS4	HYAL4	ENSOCUP00000011609	ENSOCUP00000012986	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Hyaluronidase.	0.465
ADAMTS4	MMP13	ENSOCUP00000011609	ENSOCUP00000002145	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.901
ADAMTS4	RUNX2	ENSOCUP00000011609	ENSOCUP00000010093	ADAM metallopeptidase with thrombospondin type 1 motif 4.	RUNX family transcription factor 2.	0.570
ADAMTS4	SOX9	ENSOCUP00000011609	ENSOCUP00000010009	ADAM metallopeptidase with thrombospondin type 1 motif 4.	SRY-box transcription factor 9.	0.698
ADAMTS5	ACAN	ENSOCUP00000002482	ENSOCUP00000024918	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.950
ADAMTS5	BCAN	ENSOCUP00000002482	ENSOCUP00000025883	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Brevican.	0.916
ADAMTS5	COL2A1	ENSOCUP00000002482	ENSOCUP00000011756	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Fibrillar collagen NC1 domain-containing protein.	0.865