STRINGSTRING
IL13 IL13 IL4R IL4R IL26 IL26 IL10RB IL10RB SOCS2 SOCS2 PRL PRL IL22 IL22 IRF7 IRF7 LOC100353390 LOC100353390 LOC100354397 LOC100354397 LOC100355421 LOC100355421 LOC100353390-2 LOC100353390-2 LIFR LIFR CSF2 CSF2 LIF LIF SOCS4 SOCS4 IL5 IL5 IL17A IL17A IL17F IL17F GH1 GH1 TP53BP2 TP53BP2 LOC100353137 LOC100353137 STAT5B STAT5B CNTF CNTF EPO EPO G1SPA3_RABIT G1SPA3_RABIT CTF1 CTF1 JAK1 JAK1 IL15RA IL15RA IL9 IL9 IL22RA1 IL22RA1 THPO THPO LOC100358749 LOC100358749 IL23A IL23A IL6ST IL6ST STAT6 STAT6 IL15 IL15 IL12RB2 IL12RB2 CSF3 CSF3 IL2 IL2 OSM OSM STAT3 STAT3 IL7R IL7R OSMR OSMR IL27 IL27 IFNGR1 IFNGR1 IL17RB IL17RB IL13RA1 IL13RA1 LOC100358223 LOC100358223 IL17RD IL17RD IL19 IL19 IL20 IL20 IL27RA IL27RA IL13RA2 IL13RA2 IL21 IL21 IL5RA IL5RA IL20RA IL20RA EPOR EPOR IL17B IL17B IL12B IL12B JAK2 JAK2 IFNAR2 IFNAR2 LOC100355669 LOC100355669 IL6 IL6 CSF2RB CSF2RB LOC100354654 LOC100354654 LOC100357194 LOC100357194 IL2RG IL2RG CISH CISH IL10 IL10 IFNB1 IFNB1 IL-15L IL-15L IL22RA2 IL22RA2 TSLP TSLP IFNK IFNK IL17RA IL17RA G1U0P1_RABIT G1U0P1_RABIT STAT5A STAT5A IL4 IL4 IL23R IL23R IFNGR2 IFNGR2 IFNLR1 IFNLR1 IL10RA IL10RA IFNE IFNE LOC100341420 LOC100341420 CSF2RA CSF2RA IL25 IL25 PRLR PRLR STAT4 STAT4 CSF3R CSF3R IL20RB IL20RB IL17RE IL17RE GHR GHR CLCF1 CLCF1 ENSOCUP00000035366 ENSOCUP00000035366 IL6R IL6R TYK2 TYK2 IL12A IL12A IL7 IL7 CDKL4 CDKL4 IFNG IFNG SOCS6 SOCS6 STAT1 STAT1 IL3RA IL3RA STAT2 STAT2 PTPN2 PTPN2 TRAF3IP2 TRAF3IP2 MPL MPL CNTFR CNTFR LOC100338113 LOC100338113 IL17RC IL17RC IL21R IL21R IRF1 IRF1 LOC100356937 LOC100356937 IFNAR1 IFNAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL13Interleukin 13. (138 aa)
IL4RFibronectin type-III domain-containing protein. (862 aa)
IL26Interleukin 26. (180 aa)
IL10RBInterleukin 10 receptor subunit beta. (384 aa)
SOCS2Suppressor of cytokine signaling 2. (307 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa)
IL22Interleukin 22. (187 aa)
IRF7Interferon regulatory factor 7. (438 aa)
LOC100353390Uncharacterized protein. (189 aa)
LOC100354397Uncharacterized protein. (195 aa)
LOC100355421Uncharacterized protein. (195 aa)
LOC100353390-2Uncharacterized protein. (190 aa)
LIFRLIF receptor subunit alpha. (1091 aa)
CSF2Uncharacterized protein. (144 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL17AInterleukin 17A. (153 aa)
IL17FInterleukin 17F. (163 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
TP53BP2Tumor protein p53 binding protein 2. (1133 aa)
LOC100353137Uncharacterized protein. (195 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (199 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa)
G1SPA3_RABITUncharacterized protein. (226 aa)
CTF1Cardiotrophin 1. (190 aa)
JAK1Tyrosine-protein kinase. (1151 aa)
IL15RASushi domain-containing protein. (262 aa)
IL9Interleukin 9. (143 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (679 aa)
THPOThrombopoietin. (348 aa)
LOC100358749Sushi domain-containing protein. (272 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (883 aa)
CSF3Colony stimulating factor 3. (204 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
OSMUncharacterized protein. (333 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL7RInterleukin 7 receptor. (458 aa)
OSMROncostatin M receptor. (1088 aa)
IL27Uncharacterized protein. (142 aa)
IFNGR1Interferon gamma receptor 1. (471 aa)
IL17RBInterleukin 17 receptor B. (493 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (519 aa)
LOC100358223Uncharacterized protein. (195 aa)
IL17RDInterleukin 17 receptor D. (793 aa)
IL19Interleukin 19. (233 aa)
IL20Interleukin 20. (187 aa)
IL27RAInterleukin 27 receptor subunit alpha. (634 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (361 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
IL5RAIL6Ra-bind domain-containing protein. (332 aa)
IL20RAInterleukin 20 receptor subunit alpha. (548 aa)
EPORErythropoietin receptor. (554 aa)
IL17BInterleukin 17B. (175 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
IFNAR2Uncharacterized protein. (523 aa)
LOC100355669Uncharacterized protein. (190 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (868 aa)
LOC100354654Uncharacterized protein. (189 aa)
LOC100357194Uncharacterized protein. (189 aa)
IL2RGUncharacterized protein. (171 aa)
CISHCytokine inducible SH2 containing protein. (257 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
IFNB1Interferon beta 1. (180 aa)
IL-15LInterleukin 15-like protein. (136 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
TSLPUncharacterized protein. (149 aa)
IFNKInterferon kappa. (198 aa)
IL17RAInterleukin 17 receptor A. (860 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
IL23RInterleukin 23 receptor. (622 aa)
IFNGR2Interferon gamma receptor 2. (449 aa)
IFNLR1Interferon lambda receptor 1. (639 aa)
IL10RAInterleukin 10 receptor subunit alpha. (540 aa)
IFNEInterferon epsilon. (212 aa)
LOC100341420Uncharacterized protein. (183 aa)
CSF2RAFibronectin type-III domain-containing protein. (443 aa)
IL25Interleukin 25. (177 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (640 aa)
STAT4Signal transducer and activator of transcription. (752 aa)
CSF3RColony stimulating factor 3 receptor. (1027 aa)
IL20RBInterleukin 20 receptor subunit beta. (307 aa)
IL17REInterleukin 17 receptor E. (762 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). (692 aa)
CLCF1Cardiotrophin like cytokine factor 1. (301 aa)
ENSOCUP00000035366IL17R_fnIII_D1 domain-containing protein. (331 aa)
IL6RInterleukin 6 receptor. (569 aa)
TYK2Non-specific protein-tyrosine kinase. (1065 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
CDKL4Cyclin dependent kinase like 4. (420 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
SOCS6Suppressor of cytokine signaling 6. (512 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
IL3RAUncharacterized protein. (394 aa)
STAT2STAT_int domain-containing protein. (205 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
TRAF3IP2SEFIR domain-containing protein. (559 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
CNTFRCiliary neurotrophic factor receptor. (415 aa)
LOC100338113Uncharacterized protein. (282 aa)
IL17RCInterleukin 17 receptor C. (770 aa)
IL21RUncharacterized protein. (369 aa)
IRF1Interferon regulatory factor. (336 aa)
LOC100356937Uncharacterized protein. (195 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (541 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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