(61 nodes) JAK-STAT signaling pathway network (Oryctolagus cuniculus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IL13	Interleukin 13. (138 aa)
	IL4R	Fibronectin type-III domain-containing protein. (862 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (384 aa)
	SOCS2	Suppressor of cytokine signaling 2. (307 aa)
	IL22	Interleukin 22. (187 aa)
	IRF7	Interferon regulatory factor 7. (438 aa)
	LOC100353390	Uncharacterized protein. (189 aa)
	LOC100353390-2	Uncharacterized protein. (190 aa)
	CSF2	Uncharacterized protein. (144 aa)
	SOCS4	Suppressor of cytokine signaling 4. (441 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	STAT5B	Signal transducer and activator of transcription. (786 aa)
	G1SPA3_RABIT	Uncharacterized protein. (226 aa)
	JAK1	Tyrosine-protein kinase. (1151 aa)
	IL15RA	Sushi domain-containing protein. (262 aa)
	IL9	Interleukin 9. (143 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (679 aa)
	LOC100358749	Sushi domain-containing protein. (272 aa)
	STAT6	Signal transducer and activator of transcription. (842 aa)
	IL15	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (883 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	IL7R	Interleukin 7 receptor. (458 aa)
	IFNGR1	Interferon gamma receptor 1. (471 aa)
	IL13RA1	Interleukin 13 receptor subunit alpha 1. (519 aa)
	IL13RA2	Interleukin 13 receptor subunit alpha 2. (361 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
	IL5RA	IL6Ra-bind domain-containing protein. (332 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	IFNAR2	Uncharacterized protein. (523 aa)
	LOC100355669	Uncharacterized protein. (190 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	CSF2RB	Colony stimulating factor 2 receptor beta common subunit. (868 aa)
	LOC100354654	Uncharacterized protein. (189 aa)
	LOC100357194	Uncharacterized protein. (189 aa)
	IL2RG	Uncharacterized protein. (171 aa)
	CISH	Cytokine inducible SH2 containing protein. (257 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
	IFNB1	Interferon beta 1. (180 aa)
	IL-15L	Interleukin 15-like protein. (136 aa)
	TSLP	Uncharacterized protein. (149 aa)
	STAT5A	Signal transducer and activator of transcription. (793 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
	IFNGR2	Interferon gamma receptor 2. (449 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (540 aa)
	CSF2RA	Fibronectin type-III domain-containing protein. (443 aa)
	STAT4	Signal transducer and activator of transcription. (752 aa)
	IL6R	Interleukin 6 receptor. (569 aa)
	TYK2	Non-specific protein-tyrosine kinase. (1065 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
	SOCS6	Suppressor of cytokine signaling 6. (512 aa)
	STAT1	Signal transducer and activator of transcription. (879 aa)
	IL3RA	Uncharacterized protein. (394 aa)
	STAT2	STAT_int domain-containing protein. (205 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (415 aa)
	LOC100338113	Uncharacterized protein. (282 aa)
	IL21R	Uncharacterized protein. (369 aa)
	IRF1	Interferon regulatory factor. (336 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (541 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	IFNG	ENSOCUP00000019141	ENSOCUP00000039594	Cytokine inducible SH2 containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.611
CISH	IL4	ENSOCUP00000019141	ENSOCUP00000025135	Cytokine inducible SH2 containing protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.409
CISH	IL4R	ENSOCUP00000019141	ENSOCUP00000000291	Cytokine inducible SH2 containing protein.	Fibronectin type-III domain-containing protein.	0.488
CISH	IL6	ENSOCUP00000019141	ENSOCUP00000017266	Cytokine inducible SH2 containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.459
CISH	JAK1	ENSOCUP00000019141	ENSOCUP00000005398	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.663
CISH	JAK2	ENSOCUP00000019141	ENSOCUP00000014491	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.806
CISH	SOCS2	ENSOCUP00000019141	ENSOCUP00000001084	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 2.	0.508
CISH	SOCS4	ENSOCUP00000019141	ENSOCUP00000003465	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 4.	0.612
CISH	STAT1	ENSOCUP00000019141	ENSOCUP00000039721	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.963
CISH	STAT2	ENSOCUP00000019141	ENSOCUP00000040401	Cytokine inducible SH2 containing protein.	STAT_int domain-containing protein.	0.949
CISH	STAT3	ENSOCUP00000019141	ENSOCUP00000009494	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.963
CISH	STAT4	ENSOCUP00000019141	ENSOCUP00000031601	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.947
CISH	STAT5A	ENSOCUP00000019141	ENSOCUP00000024325	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.963
CISH	STAT5B	ENSOCUP00000019141	ENSOCUP00000004399	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.956
CISH	STAT6	ENSOCUP00000019141	ENSOCUP00000006856	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.957
CISH	TYK2	ENSOCUP00000019141	ENSOCUP00000036146	Cytokine inducible SH2 containing protein.	Non-specific protein-tyrosine kinase.	0.647
CSF2	CSF2RA	ENSOCUP00000002976	ENSOCUP00000030014	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.999
CSF2	CSF2RB	ENSOCUP00000002976	ENSOCUP00000017348	Uncharacterized protein.	Colony stimulating factor 2 receptor beta common subunit.	0.997
CSF2	G1SPA3_RABIT	ENSOCUP00000002976	ENSOCUP00000004859	Uncharacterized protein.	Uncharacterized protein.	0.773
CSF2	IFNAR1	ENSOCUP00000002976	ENSOCUP00000048315	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.794