STRINGSTRING
IL13 IL13 IL4R IL4R IL10RB IL10RB IL22 IL22 CSF2 CSF2 IL5 IL5 IL22RA1 IL22RA1 IL12RB2 IL12RB2 IL13RA1 IL13RA1 IL13RA2 IL13RA2 IL5RA IL5RA IL6 IL6 CSF2RB CSF2RB IL10 IL10 IL4 IL4 IL10RA IL10RA CSF2RA CSF2RA IL6R IL6R IL3RA IL3RA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL13Interleukin 13. (138 aa)
IL4RFibronectin type-III domain-containing protein. (862 aa)
IL10RBInterleukin 10 receptor subunit beta. (384 aa)
IL22Interleukin 22. (187 aa)
CSF2Uncharacterized protein. (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (679 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (883 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (519 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (361 aa)
IL5RAIL6Ra-bind domain-containing protein. (332 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (868 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
IL10RAInterleukin 10 receptor subunit alpha. (540 aa)
CSF2RAFibronectin type-III domain-containing protein. (443 aa)
IL6RInterleukin 6 receptor. (569 aa)
IL3RAUncharacterized protein. (394 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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