(5 nodes) Interleukins 4 and 13, and Short hematopoietin receptor, family 2, conserved site network (Oryctolagus cuniculus)

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Your Input:
	IL13	Interleukin 13. (138 aa)
	IL4R	Fibronectin type-III domain-containing protein. (862 aa)
	IL13RA1	Interleukin 13 receptor subunit alpha 1. (519 aa)
	IL13RA2	Interleukin 13 receptor subunit alpha 2. (361 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL13	IL13RA1	ENSOCUP00000000136	ENSOCUP00000011781	Interleukin 13.	Interleukin 13 receptor subunit alpha 1.	0.998
IL13	IL13RA2	ENSOCUP00000000136	ENSOCUP00000012677	Interleukin 13.	Interleukin 13 receptor subunit alpha 2.	0.999
IL13	IL4	ENSOCUP00000000136	ENSOCUP00000025135	Interleukin 13.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.988
IL13	IL4R	ENSOCUP00000000136	ENSOCUP00000000291	Interleukin 13.	Fibronectin type-III domain-containing protein.	0.993
IL13RA1	IL13	ENSOCUP00000011781	ENSOCUP00000000136	Interleukin 13 receptor subunit alpha 1.	Interleukin 13.	0.998
IL13RA1	IL13RA2	ENSOCUP00000011781	ENSOCUP00000012677	Interleukin 13 receptor subunit alpha 1.	Interleukin 13 receptor subunit alpha 2.	0.702
IL13RA1	IL4	ENSOCUP00000011781	ENSOCUP00000025135	Interleukin 13 receptor subunit alpha 1.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.999
IL13RA1	IL4R	ENSOCUP00000011781	ENSOCUP00000000291	Interleukin 13 receptor subunit alpha 1.	Fibronectin type-III domain-containing protein.	0.989
IL13RA2	IL13	ENSOCUP00000012677	ENSOCUP00000000136	Interleukin 13 receptor subunit alpha 2.	Interleukin 13.	0.999
IL13RA2	IL13RA1	ENSOCUP00000012677	ENSOCUP00000011781	Interleukin 13 receptor subunit alpha 2.	Interleukin 13 receptor subunit alpha 1.	0.702
IL13RA2	IL4	ENSOCUP00000012677	ENSOCUP00000025135	Interleukin 13 receptor subunit alpha 2.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.961
IL13RA2	IL4R	ENSOCUP00000012677	ENSOCUP00000000291	Interleukin 13 receptor subunit alpha 2.	Fibronectin type-III domain-containing protein.	0.937
IL4	IL13	ENSOCUP00000025135	ENSOCUP00000000136	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Interleukin 13.	0.988
IL4	IL13RA1	ENSOCUP00000025135	ENSOCUP00000011781	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Interleukin 13 receptor subunit alpha 1.	0.999
IL4	IL13RA2	ENSOCUP00000025135	ENSOCUP00000012677	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Interleukin 13 receptor subunit alpha 2.	0.961
IL4	IL4R	ENSOCUP00000025135	ENSOCUP00000000291	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Fibronectin type-III domain-containing protein.	0.999
IL4R	IL13	ENSOCUP00000000291	ENSOCUP00000000136	Fibronectin type-III domain-containing protein.	Interleukin 13.	0.993
IL4R	IL13RA1	ENSOCUP00000000291	ENSOCUP00000011781	Fibronectin type-III domain-containing protein.	Interleukin 13 receptor subunit alpha 1.	0.989
IL4R	IL13RA2	ENSOCUP00000000291	ENSOCUP00000012677	Fibronectin type-III domain-containing protein.	Interleukin 13 receptor subunit alpha 2.	0.937
IL4R	IL4	ENSOCUP00000000291	ENSOCUP00000025135	Fibronectin type-III domain-containing protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.999