(5 nodes) Interleukin-10 signaling, and interleukin-20 binding network (Oryctolagus cuniculus)

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Your Input:
	IL10RB	Interleukin 10 receptor subunit beta. (384 aa)
	IL22	Interleukin 22. (187 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (679 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (540 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RA	ENSOCUP00000019534	ENSOCUP00000027490	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.999
IL10	IL10RB	ENSOCUP00000019534	ENSOCUP00000001025	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.996
IL10	IL22	ENSOCUP00000019534	ENSOCUP00000001423	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.905
IL10	IL22RA1	ENSOCUP00000019534	ENSOCUP00000005829	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.808
IL10RA	IL10	ENSOCUP00000027490	ENSOCUP00000019534	Interleukin 10 receptor subunit alpha.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.999
IL10RA	IL10RB	ENSOCUP00000027490	ENSOCUP00000001025	Interleukin 10 receptor subunit alpha.	Interleukin 10 receptor subunit beta.	0.996
IL10RA	IL22	ENSOCUP00000027490	ENSOCUP00000001423	Interleukin 10 receptor subunit alpha.	Interleukin 22.	0.831
IL10RA	IL22RA1	ENSOCUP00000027490	ENSOCUP00000005829	Interleukin 10 receptor subunit alpha.	Interleukin 22 receptor subunit alpha 1.	0.795
IL10RB	IL10	ENSOCUP00000001025	ENSOCUP00000019534	Interleukin 10 receptor subunit beta.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.996
IL10RB	IL10RA	ENSOCUP00000001025	ENSOCUP00000027490	Interleukin 10 receptor subunit beta.	Interleukin 10 receptor subunit alpha.	0.996
IL10RB	IL22	ENSOCUP00000001025	ENSOCUP00000001423	Interleukin 10 receptor subunit beta.	Interleukin 22.	0.990
IL10RB	IL22RA1	ENSOCUP00000001025	ENSOCUP00000005829	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 1.	0.992
IL22	IL10	ENSOCUP00000001423	ENSOCUP00000019534	Interleukin 22.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.905
IL22	IL10RA	ENSOCUP00000001423	ENSOCUP00000027490	Interleukin 22.	Interleukin 10 receptor subunit alpha.	0.831
IL22	IL10RB	ENSOCUP00000001423	ENSOCUP00000001025	Interleukin 22.	Interleukin 10 receptor subunit beta.	0.990
IL22	IL22RA1	ENSOCUP00000001423	ENSOCUP00000005829	Interleukin 22.	Interleukin 22 receptor subunit alpha 1.	0.999
IL22RA1	IL10	ENSOCUP00000005829	ENSOCUP00000019534	Interleukin 22 receptor subunit alpha 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.808
IL22RA1	IL10RA	ENSOCUP00000005829	ENSOCUP00000027490	Interleukin 22 receptor subunit alpha 1.	Interleukin 10 receptor subunit alpha.	0.795
IL22RA1	IL10RB	ENSOCUP00000005829	ENSOCUP00000001025	Interleukin 22 receptor subunit alpha 1.	Interleukin 10 receptor subunit beta.	0.992
IL22RA1	IL22	ENSOCUP00000005829	ENSOCUP00000001423	Interleukin 22 receptor subunit alpha 1.	Interleukin 22.	0.999