(19 nodes) IL-6-type cytokine receptor ligand interactions, and Growth hormone/erythropoietin receptor, ligand binding network (Oryctolagus cuniculus)

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Your Input:
	PRL	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa)
	LIFR	LIF receptor subunit alpha. (1091 aa)
	LIF	LIF interleukin 6 family cytokine. (203 aa)
	GH1	Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
	CNTF	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (199 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa)
	CTF1	Cardiotrophin 1. (190 aa)
	THPO	Thrombopoietin. (348 aa)
	IL6ST	Interleukin 6 signal transducer. (918 aa)
	CSF3	Colony stimulating factor 3. (204 aa)
	OSM	Uncharacterized protein. (333 aa)
	OSMR	Oncostatin M receptor. (1088 aa)
	EPOR	Erythropoietin receptor. (554 aa)
	PRLR	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (640 aa)
	CSF3R	Colony stimulating factor 3 receptor. (1027 aa)
	GHR	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). (692 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (301 aa)
	MPL	MPL proto-oncogene, thrombopoietin receptor. (635 aa)
	CNTFR	Ciliary neurotrophic factor receptor. (415 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCF1	CNTF	ENSOCUP00000035345	ENSOCUP00000004675	Cardiotrophin like cytokine factor 1.	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	0.840
CLCF1	CNTFR	ENSOCUP00000035345	ENSOCUP00000043912	Cardiotrophin like cytokine factor 1.	Ciliary neurotrophic factor receptor.	0.985
CLCF1	CTF1	ENSOCUP00000035345	ENSOCUP00000004929	Cardiotrophin like cytokine factor 1.	Cardiotrophin 1.	0.681
CLCF1	IL6ST	ENSOCUP00000035345	ENSOCUP00000006777	Cardiotrophin like cytokine factor 1.	Interleukin 6 signal transducer.	0.926
CLCF1	LIF	ENSOCUP00000035345	ENSOCUP00000003262	Cardiotrophin like cytokine factor 1.	LIF interleukin 6 family cytokine.	0.488
CLCF1	LIFR	ENSOCUP00000035345	ENSOCUP00000002891	Cardiotrophin like cytokine factor 1.	LIF receptor subunit alpha.	0.974
CLCF1	OSM	ENSOCUP00000035345	ENSOCUP00000008790	Cardiotrophin like cytokine factor 1.	Uncharacterized protein.	0.547
CLCF1	OSMR	ENSOCUP00000035345	ENSOCUP00000010891	Cardiotrophin like cytokine factor 1.	Oncostatin M receptor.	0.501
CLCF1	PRLR	ENSOCUP00000035345	ENSOCUP00000030796	Cardiotrophin like cytokine factor 1.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.868
CNTF	CLCF1	ENSOCUP00000004675	ENSOCUP00000035345	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Cardiotrophin like cytokine factor 1.	0.840
CNTF	CNTFR	ENSOCUP00000004675	ENSOCUP00000043912	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Ciliary neurotrophic factor receptor.	0.999
CNTF	CSF3	ENSOCUP00000004675	ENSOCUP00000008356	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Colony stimulating factor 3.	0.918
CNTF	CSF3R	ENSOCUP00000004675	ENSOCUP00000031815	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Colony stimulating factor 3 receptor.	0.748
CNTF	CTF1	ENSOCUP00000004675	ENSOCUP00000004929	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Cardiotrophin 1.	0.854
CNTF	EPO	ENSOCUP00000004675	ENSOCUP00000004681	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.926
CNTF	EPOR	ENSOCUP00000004675	ENSOCUP00000013491	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Erythropoietin receptor.	0.694
CNTF	GH1	ENSOCUP00000004675	ENSOCUP00000003753	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family.	0.900
CNTF	GHR	ENSOCUP00000004675	ENSOCUP00000033529	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	0.650
CNTF	IL6ST	ENSOCUP00000004675	ENSOCUP00000006777	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	Interleukin 6 signal transducer.	0.949
CNTF	LIF	ENSOCUP00000004675	ENSOCUP00000003262	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	LIF interleukin 6 family cytokine.	0.915