STRINGSTRING
HNRNPC HNRNPC HNRNPD HNRNPD HNRNPR HNRNPR HNRNPK HNRNPK HNRNPA1 HNRNPA1 HNRNPA2B1 HNRNPA2B1 HNRNPL HNRNPL HNRNPF HNRNPF HNRNPH1 HNRNPH1 HNRNPU HNRNPU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HNRNPCHeterogeneous nuclear ribonucleoprotein C; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilit [...] (306 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (286 aa)
HNRNPRHeterogeneous nuclear ribonucleoprotein R. (635 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)
HNRNPA1Uncharacterized protein. (371 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (352 aa)
HNRNPLHeterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
HNRNPFUncharacterized protein. (543 aa)
HNRNPH1Heterogeneous nuclear ribonucleoprotein H1. (591 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (844 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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