(5 nodes) Mixed, incl. Protein localization to spindle microtubule, and ROK, N-terminal network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	HNRNPR	Heterogeneous nuclear ribonucleoprotein R. (635 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)
	HNRNPA1	Uncharacterized protein. (371 aa)
	HNRNPL	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (844 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HNRNPA1	HNRNPK	ENSOCUP00000011492	ENSOCUP00000008932	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.932
HNRNPA1	HNRNPL	ENSOCUP00000011492	ENSOCUP00000023948	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.867
HNRNPA1	HNRNPR	ENSOCUP00000011492	ENSOCUP00000005778	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein R.	0.789
HNRNPA1	HNRNPU	ENSOCUP00000011492	ENSOCUP00000044849	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein U.	0.926
HNRNPK	HNRNPA1	ENSOCUP00000008932	ENSOCUP00000011492	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	Uncharacterized protein.	0.932
HNRNPK	HNRNPL	ENSOCUP00000008932	ENSOCUP00000023948	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.927
HNRNPK	HNRNPR	ENSOCUP00000008932	ENSOCUP00000005778	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	Heterogeneous nuclear ribonucleoprotein R.	0.823
HNRNPK	HNRNPU	ENSOCUP00000008932	ENSOCUP00000044849	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	Heterogeneous nuclear ribonucleoprotein U.	0.954
HNRNPL	HNRNPA1	ENSOCUP00000023948	ENSOCUP00000011492	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.867
HNRNPL	HNRNPK	ENSOCUP00000023948	ENSOCUP00000008932	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.927
HNRNPL	HNRNPR	ENSOCUP00000023948	ENSOCUP00000005778	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	Heterogeneous nuclear ribonucleoprotein R.	0.883
HNRNPL	HNRNPU	ENSOCUP00000023948	ENSOCUP00000044849	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	Heterogeneous nuclear ribonucleoprotein U.	0.908
HNRNPR	HNRNPA1	ENSOCUP00000005778	ENSOCUP00000011492	Heterogeneous nuclear ribonucleoprotein R.	Uncharacterized protein.	0.789
HNRNPR	HNRNPK	ENSOCUP00000005778	ENSOCUP00000008932	Heterogeneous nuclear ribonucleoprotein R.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.823
HNRNPR	HNRNPL	ENSOCUP00000005778	ENSOCUP00000023948	Heterogeneous nuclear ribonucleoprotein R.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.883
HNRNPR	HNRNPU	ENSOCUP00000005778	ENSOCUP00000044849	Heterogeneous nuclear ribonucleoprotein R.	Heterogeneous nuclear ribonucleoprotein U.	0.884
HNRNPU	HNRNPA1	ENSOCUP00000044849	ENSOCUP00000011492	Heterogeneous nuclear ribonucleoprotein U.	Uncharacterized protein.	0.926
HNRNPU	HNRNPK	ENSOCUP00000044849	ENSOCUP00000008932	Heterogeneous nuclear ribonucleoprotein U.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.954
HNRNPU	HNRNPL	ENSOCUP00000044849	ENSOCUP00000023948	Heterogeneous nuclear ribonucleoprotein U.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.908
HNRNPU	HNRNPR	ENSOCUP00000044849	ENSOCUP00000005778	Heterogeneous nuclear ribonucleoprotein U.	Heterogeneous nuclear ribonucleoprotein R.	0.884