40 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G1SCF2_RABIT	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (175 aa)
	COPS6	COP9 signalosome subunit 6. (324 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
	GAN	Gigaxonin. (587 aa)
	DDB1	Damage specific DNA binding protein 1. (1140 aa)
	G1SG29_RABIT	Skp1_POZ domain-containing protein. (72 aa)
	DDB2	Damage specific DNA binding protein 2. (427 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	CAND1	Cullin associated and neddylation dissociated 1. (1207 aa)
	COP1	COP1 E3 ubiquitin ligase. (733 aa)
	COPS2	COP9 signalosome subunit 2. (450 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1507 aa)
	COPS5	COP9 signalosome subunit 5. (334 aa)
	DCUN1D4	DCN1-like protein. (285 aa)
	DCUN1D1	DCN1-like protein. (345 aa)
	PPP1R42	Protein phosphatase 1 regulatory subunit 42. (310 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	UBE2M	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
	DET1	Uncharacterized protein. (553 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	SENP8	SUMO peptidase family member, NEDD8 specific. (212 aa)
	G1U1I7_RABIT	Uncharacterized protein. (91 aa)
	BTBD6	BTB domain containing 6. (410 aa)
	COPS3	COP9 signalosome subunit 3. (423 aa)
	COPS7B	COP9 signalosome subunit 7B. (274 aa)
	VHL	Uncharacterized protein. (191 aa)
	COPS4	COP9 signalosome subunit 4. (410 aa)
	UBE2F	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
	ENSOCUP00000034885	Uncharacterized protein. (128 aa)
	ENSOCUP00000035728	Zf-rbx1 domain-containing protein. (160 aa)
	ENSOCUP00000036818	Uncharacterized protein. (69 aa)
	COPS8	PCI domain-containing protein. (298 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	COPS7A	COP9 signalosome subunit 7A. (344 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (901 aa)
	ENSOCUP00000041941	CSN8_PSD8_EIF3K domain-containing protein. (170 aa)
	ERCC8	ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (410 aa)
	DCUN1D2	DCN1-like protein. (250 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD6	CAND1	ENSOCUP00000026037	ENSOCUP00000004347	BTB domain containing 6.	Cullin associated and neddylation dissociated 1.	0.718
BTBD6	CUL1	ENSOCUP00000026037	ENSOCUP00000002198	BTB domain containing 6.	Cullin 1; Belongs to the cullin family.	0.466
BTBD6	CUL2	ENSOCUP00000026037	ENSOCUP00000012675	BTB domain containing 6.	Cullin 2; Belongs to the cullin family.	0.402
BTBD6	DCUN1D1	ENSOCUP00000026037	ENSOCUP00000010659	BTB domain containing 6.	DCN1-like protein.	0.529
BTBD6	DCUN1D2	ENSOCUP00000026037	ENSOCUP00000046591	BTB domain containing 6.	DCN1-like protein.	0.508
BTBD6	DCUN1D3	ENSOCUP00000026037	ENSOCUP00000016804	BTB domain containing 6.	DCN1-like protein.	0.431
BTBD6	DCUN1D4	ENSOCUP00000026037	ENSOCUP00000010634	BTB domain containing 6.	DCN1-like protein.	0.518
BTBD6	ENSOCUP00000035728	ENSOCUP00000026037	ENSOCUP00000035728	BTB domain containing 6.	Zf-rbx1 domain-containing protein.	0.530
BTBD6	GAN	ENSOCUP00000026037	ENSOCUP00000000930	BTB domain containing 6.	Gigaxonin.	0.763
BTBD6	NAE1	ENSOCUP00000026037	ENSOCUP00000000498	BTB domain containing 6.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.529
BTBD6	NEDD8	ENSOCUP00000026037	ENSOCUP00000002526	BTB domain containing 6.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.530
BTBD6	UBA3	ENSOCUP00000026037	ENSOCUP00000007065	BTB domain containing 6.	Ubiquitin like modifier activating enzyme 3.	0.520
BTBD6	UBE2M	ENSOCUP00000026037	ENSOCUP00000014290	BTB domain containing 6.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.530
CAND1	BTBD6	ENSOCUP00000004347	ENSOCUP00000026037	Cullin associated and neddylation dissociated 1.	BTB domain containing 6.	0.718
CAND1	COPS4	ENSOCUP00000004347	ENSOCUP00000030520	Cullin associated and neddylation dissociated 1.	COP9 signalosome subunit 4.	0.442
CAND1	COPS5	ENSOCUP00000004347	ENSOCUP00000009878	Cullin associated and neddylation dissociated 1.	COP9 signalosome subunit 5.	0.541
CAND1	COPS6	ENSOCUP00000004347	ENSOCUP00000000260	Cullin associated and neddylation dissociated 1.	COP9 signalosome subunit 6.	0.401
CAND1	CUL1	ENSOCUP00000004347	ENSOCUP00000002198	Cullin associated and neddylation dissociated 1.	Cullin 1; Belongs to the cullin family.	0.999
CAND1	CUL2	ENSOCUP00000004347	ENSOCUP00000012675	Cullin associated and neddylation dissociated 1.	Cullin 2; Belongs to the cullin family.	0.927
CAND1	CUL4B	ENSOCUP00000004347	ENSOCUP00000040452	Cullin associated and neddylation dissociated 1.	Cullin 4B; Belongs to the cullin family.	0.965